SHH

[Cell Death & Disease] Scientists explore the emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor in controlling cellular genes that regulate cardiometabolic function.

[Cell Death & Disease] The authors identified the molecular mechanism of Sonic hedgehog (Shh)-mediated mutation-independent Imatinib resistance that is most relevant for treating chronic myeloid leukemia-variants and non-compliant patients.

[Scientific Reports] When grown under the same stem cell enriching conditions, SHH subgroup medulloblastoma cell lines established tight, highly reproducible 3D spheroids that could be maintained for weeks in culture and formed pathophysiological oxygen gradients.

[Cell Death & Disease] Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.

[Cancers] Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.

[Nature Cell Biology] Researchers presented a versatile optogenetic toolbox of artificial multi-headed myosin motors that could move bidirectionally within long cellular extensions and allowed for the selective transport of GFP-tagged cargo with light.