The Role of Smoothened in Cancer

Smoothened (SMO) expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity.
[International Journal of Medical Sciences]
Jeng, K.-S., Sheen, I.-S., Leu, C.-M., Tseng, P.-H., & Chang, C.-F. (2020). The Role of Smoothened in Cancer. International Journal of Molecular Sciences, 21(18), 6863. https://doi.org/10.3390/ijms21186863 Cite
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Combined Inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 Pathways Suppresses Breast Cancer Stem Cells, Tumor Growth, and Metastasis

Investigators showed that novel combinations of JAK2 inhibitors with SMO inhibitors synergistically inhibited in vitro growth of TNBC and HER2-positive trastuzumab-resistant BT474-TtzmR cells.
[Oncogene]
Doheny, D., Sirkisoon, S., Carpenter, R. L., Aguayo, N. R., Regua, A. T., Anguelov, M., Manore, S. G., Arrigo, A., Jalboush, S. A., Wong, G. L., Yu, Y., Wagner, C. J., Chan, M., Ruiz, J., Thomas, A., Strowd, R., Lin, J., & Lo, H.-W. (2020). Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01454-1 Cite
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Garcinone C Suppresses Colon Tumorigenesis through the Gli1-dependent Hedgehog Signaling Pathway

Colony formation assay and flow cytometry were used to evaluate the effect of garcinone C on the proliferation and cell cycle progression of colon cancer cells.
[Phytomedicine]
Chen, J., Qiu, S., Kim, J. T., Cho, J. S., Moon, J. H., Zhou, Y., Auh, J.-H., & Lee, H. J. (2020). Garcinone C Suppresses Colon Tumorigenesis Through the Gli1-dependent Hedgehog Signaling Pathway. Phytomedicine, 153334. https://doi.org/10.1016/j.phymed.2020.153334 Cite
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