SMO

[Pharmacological Research] Scientists found that fibroblast growth factor 18 was markedly upregulated in carbon tetrachloride-induced fibrotic mouse liver tissues and transforming growth factor β stimulated LX-2 cells.

[Laboratory Investigation] Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B-cell lymphoma.

[Diabetes Research and Clinical Practice] Scientists illustrated the molecular mechanisms by which Forkhead box M1 (FOXM1) enhanced M2 polarization and wound healing of diabetic foot ulcer.

[Nature Communications] Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.

[iScience] Investigators examined dietary cholesterol-induced reorganization of whole body sterol and bile acid homeostasis in adult mice with inducible hepatocyte-specific Smo deletion. They demonstrated Smo in hepatocytes played a regulatory role in sensing and feedback regulation of cholesterol balance driven by excess dietary cholesterol.

[Scientific Reports] Researchers investigated the role of Hedgehog-GLI signaling in sustaining androgen-independent growth of prostate cancer cells.