STAT3

[Leukemia] By using TL1, a human T-LGL cell line, the authors could show that miR-181a was an actor in T-LGL leukemia, driving STAT3 activation by SOCS3 inhibition and ERK1/2 phosphorylation by DUSP6 inhibition and verified this mechanism in an independent cell line.

[Amb Express] Administration of polysaccharide Pleurotus ostreatus showed a significant decrease in tumor cell metastasis while the increase in the survival period among mice models of H22 malignant ascites.

[Oncogene] Researchers demonstrate that lung adenocarcinoma was suppressed in oncogenic KrasG12D-driven mouse models engineered for pS727-STAT3 deficiency.

[iScience] Researchers examined the significance of olfactory receptor (OR) transcript abundance in primary and metastatic breast cancer to the brain, bone, and lung. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells as well as metastasis to different organs.

[Journal of Biochemistry] Using ectopic plasmid incorporation and siRNA assays, investigators analyzed the circRPPH1-mediated regulation of cell proliferation, migration, and invasion in NSCLC cell lines, using CCK-8, colony forming, scratch wound, and transwell assays, respectively.

[Cell Research] Guided by insights from a large-scale single-cell transcriptome analysis of pig embryos from embryonic day (E) 0 to E14, the authors developed an in vitro culture medium for establishing and maintaining stable PSC lines from pig E10 pregastrulation epiblasts.