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STAT3

Application of a Fluorescent H2S Probe Based on Excited-State Intramolecular Proton Transfer for Detecting Latent Mechanism of H2S-Induced MCF-7 Apoptosis

[Future Medicinal Chemistry] FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect H2S in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis.

CircTCF25 Serves as a Sponge for MiR-206 to Support Proliferation, Migration, and Invasion of Glioma via the Jak2/P-Stat3/CypB Axis

[Molecular Carcinogenesis] RNA TCF25 (circTCF25) was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reversed the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells.

RBMS1 Promotes Gastric Cancer Metastasis through Autocrine IL-6/JAK2/STAT3 Signaling

[Cell Death & Disease] Researchers explored a prognostic model for the estimation of tumor-associated mortality in gastric cancer (GC) patients and revealed the RNA-binding protein RBMS1 as a candidate promoter gene for GC metastasis by analyzing GOBO and oncomine high-throughput sequencing datasets for 408 GC patients.

The Expression of PD-1 Ligand 1 on Macrophages and Its Clinical Impacts and Mechanisms in Lung Adenocarcinoma

[Cancer Immunology Immunotherapy] In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate programmed cell death-1 ligand 1 expression on macrophages via STAT3 activation.

Alpha-7 Nicotinic Acetylcholine Receptor Agonist Alleviates Psoriasis-Like Inflammation through Inhibition of the STAT3 and NF-κB Signaling Pathway

[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.

IL-6 Promotes Chemoresistance via Upregulating CD36 Mediated Fatty Acids Uptake in Acute Myeloid Leukemia

[Experimental Cell Research] The authors found that lipid transport-associated genes were upregulated in the high interleukin-6 (IL-6) receptor expression group. IL-6 promoted fatty acid uptake in both AML cell lines and primary AML cells.

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