Tag results:
STAT3
Mammary Cell News
Application of a Fluorescent H2S Probe Based on Excited-State Intramolecular Proton Transfer for Detecting Latent Mechanism of H2S-Induced MCF-7 Apoptosis
[Future Medicinal Chemistry] FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect H2S in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis.
Neural Cell News
CircTCF25 Serves as a Sponge for MiR-206 to Support Proliferation, Migration, and Invasion of Glioma via the Jak2/P-Stat3/CypB Axis
[Molecular Carcinogenesis] RNA TCF25 (circTCF25) was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reversed the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells.
Intestinal Cell News
RBMS1 Promotes Gastric Cancer Metastasis through Autocrine IL-6/JAK2/STAT3 Signaling
[Cell Death & Disease] Researchers explored a prognostic model for the estimation of tumor-associated mortality in gastric cancer (GC) patients and revealed the RNA-binding protein RBMS1 as a candidate promoter gene for GC metastasis by analyzing GOBO and oncomine high-throughput sequencing datasets for 408 GC patients.
Pulmonary Cell News
The Expression of PD-1 Ligand 1 on Macrophages and Its Clinical Impacts and Mechanisms in Lung Adenocarcinoma
[Cancer Immunology Immunotherapy] In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate programmed cell death-1 ligand 1 expression on macrophages via STAT3 activation.
Dermal Cell News
Alpha-7 Nicotinic Acetylcholine Receptor Agonist Alleviates Psoriasis-Like Inflammation through Inhibition of the STAT3 and NF-κB Signaling Pathway
[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.
Hematopoiesis News
IL-6 Promotes Chemoresistance via Upregulating CD36 Mediated Fatty Acids Uptake in Acute Myeloid Leukemia
[Experimental Cell Research] The authors found that lipid transport-associated genes were upregulated in the high interleukin-6 (IL-6) receptor expression group. IL-6 promoted fatty acid uptake in both AML cell lines and primary AML cells.