STAT3

[International Journal of Oncology] Researchers examined the competing endogenous RNA network in cutaneous squamous cell carcinoma.

[Scientific Reports] The authors found that treatment of highly metastatic tumor-conditioned medium induced resistance to 5-fluorouracil with interleukin-6 upregulation in endothelial cells.

[European Journal of Pharmacology] Researchers studied atorvastatin effects on the angiogenesis-signaling pathways from MSCs' differentiation to tissue angiogenesis.

[Blood] Mice with constitutive activation of mechanistic target of rapamycin complex signaling in osteocytes exhibited a dramatic increase in IL-19 production and promyelocyte/myelocytic expansion, whereas mTORC1 inactivation in osteocytes reduced IL-19 production and neutrophil numbers in mice.

[Nature Medicine] Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the molecular mechanism whereby Stat3 regulates skeletal development and osteoblast differentiation.