STAT3

[Proceedings of the National Academy of Sciences of the United States of America] The authors reported that in mouse T helper 17 (Th17) cells, Stat3 phosphorylation at serine 727, required for its transcriptional activity, was carried out by homeodomain-interacting protein kinase 2 (HIPK2), a nuclear kinase selectively up-regulated in Th17 cells, but not other Th subtypes that have distinct functions in immunity.

[Scientific Reports] Researchers examined the role of interleukin-6 (IL-6) in defective angiogenesis mediated by leucine-rich α-2-glycoprotein 1 (LRG1). IL-6 treatment induced LRG1 expression in endothelial cells and ex vivo angiogenesis cultures and promoted vascular growth with reduced mural cell coverage.

[Journal of Controlled Release] Scientists found that exosomes from primary brain tumors could upregulate the expression of lipocalin-2 in bEnd.3 brain microvascular endothelial cells

[Journal of Nanobiotechnology] A nanocomposite-based hydrogel was constructed by loading methotrexate into ZnO/Ag to realize combined multiple target therapy of psoriasis.

[Experimental Dermatology] Researchers identified that circular RNA EIF5 (circEIF5) was highly expressed in psoriasis tissues compared to the normal skin.

[Inflammation] Investigators found that circular RNA OAS3 (circOAS3) expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.