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STAT3

Membrane Progesterone Receptor α (mPRα) Enhances Hypoxia-Induced Vascular Endothelial Growth Factor Secretion and Angiogenesis in Lung Adenocarcinoma through STAT3 Signaling

[Journal of Translational Medicine] Membrane progesterone receptor α was deregulated within lung adenocarcinoma (LUAD) tissue samples; increased membrane progesterone receptor α contributed to a higher microvessel density in LUAD tissues.

Synthetic Adiponectin-Receptor Agonist, AdipoRon, Induces Glycolytic Dependence in Pancreatic Cancer Cells

[Cell Death & Disease] Treatment of PDAC cells with AdipoRon led to mitochondrial uncoupling and loss of ATP production. Concomitantly, AdipoRon-treated cells increased glucose uptake and utilization.

Ultrasound Targeted Microbubble Destruction-Mediated SOCS3 Attenuates Biological Characteristics and Epithelial-Mesenchymal Transition (EMT) of Breast Cancer Stem Cells

[Bioengineered] The authors explored the effects of ultrasound targeted microbubble destruction -mediated transfection of SOCS3 on the biological characteristics and EMT of breast cancer stem cells.

MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

[Stem Cells International] Researchers explored whether Mesenchymal stem cell- (MSC-) derived extracellular vesicles-delivered lipocalin-type prostaglandin D2 synthase (L-PGDS) could inhibit gastric cancer progression.

Modulating Oxidative Stress in B Cells Promotes Immunotherapy in Food Allergy

[Oxidative Medicine and Cellular Longevity] Researchers investigated the role of flagellin in promoting immunotherapy efficacy through modulating oxidative stress in regulatory B cells.

NCAPD3 Promotes Prostate Cancer Progression by Up-Regulating EZH2 and MALAT1 through STAT3 and E2F1

[Cellular Signalling] In vitro and in vivo functional characterization revealed that overexpression of NCAPD3 enhanced the growth of prostate cancer (PCa) cells, while knockdown of NCAPD3 impaired the growth of PCa cells.

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