Using patient samples and a mouse model, scientists demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that were associated with increased Fas-mediated apoptosis.
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
The average survival time was shorter in patients with JAK/STAT and PHF6 comutation than that in other patients, suggesting a potential role of PHF6 in leukemia progression.
[zotpress userid=’7992332′ items=’5Y56UTLE’ style=’apa’ cite=’yes’]
Investigators reported that the epigenetic factor, Ten-Eleven Translocation 3 (TET3) dioxygenase was overexpressed in acute myeloid leukemia (AML) patients and functionally validated human leukemic stem cells, and was required for leukemic growth by virtue of its regulation of glucose metabolism in AML cells.
[zotpress userid=’7992332′ items=’PEW3C5LM’ style=’apa’ cite=’yes’]
The ability of CCT245718 to overcome TKD-mediated resistance was evaluated in a cell line-based model of drug resistance to Fms-like tyrosine kinase 3 (FLT3) inhibitors.
[British Journal of Cancer]
[zotpress userid=’7992332′ items=’DL6RLTR4′ style=’apa’ cite=’yes’]
Scientists found STAT5B to be specifically activated in HSCs and leukemic stem cells, where it induced many genes associated with quiescence and self-renewal, including the surface marker CD9.
[zotpress userid=’7992332′ items=’JWFUD92W’ style=’apa’ cite=’yes’]
Investigators used whole-genome analyses to show that the transcriptional program and epigenetic features of Treg cells were attenuated in the absence of Tet2 and Tet3.
[zotpress userid=” items=’SAE267M7′ style=’apa’ cite=’yes’]
Researchers found that erythropoietin (EPO) promoted the formation of abdominal aortic aneurysm (AAA) in both Apoe−/− and wild type mice by enhancing angiogenesis, inflammation, collagen degradation, and apoptosis of smooth muscle cells and that EPO/EPO receptor signaling was essential for angiotensin II-induced AAA.
[Science Translational Medicine]
[zotpress userid=” items=’QW34R5XW’ style=’apa’ cite=’yes’]
WZ-2-033 significantly inhibited the proliferation, colony survival, migration, and invasion of TNBC cells and gastric cancer cells with aberrant signal transducer and activator of transcription 3 (STAT3) activation.
[Acta Pharmacologica Sinica]
[zotpress userid=’7992332′ items=’BEG8IJZJ’ style=’apa’ cite=’yes’]
The authors built mouse models expressing activated Il7r (aIL7R). B-cell intrinsic aIL7R mice developed spontaneous B-cell acute lymphoblastic leukemia, demonstrating sufficiency of Il7r activating mutations in leukemogenesis.
[zotpress userid=’7992332′ items=’2MSE27NS’ style=’apa’ cite=’yes’]
Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.
[Signal Transduction and Targeted Therapy]
[zotpress userid=’7992332′ items=’W7BW3ME5′ style=’apa’ cite=’yes’]
The authors reported that cabozantinib could promote differentiation in erythroid leukemia cells and found that K562 erythroid leukemia cells treated with 1 μM cabozantinib for 72 hours underwent erythroid lineage differentiation.
[Cancer Gene Therapy]
[zotpress userid=” items=’E3U7D9BW’ style=’apa’ cite=’yes’]