Tag results:

STAT5

PI3Kδ Coordinates Transcriptional, Chromatin, and Metabolic Changes to Promote Effector CD8+ T Cells at the Expense of Central Memory

[Cell Reports] Using patient samples and a mouse model, scientists demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that were associated with increased Fas-mediated apoptosis.

PHF6 and JAK3 Mutations Cooperate to Drive T-Cell Acute Lymphoblastic Leukemia Progression

[Leukemia] The average survival time was shorter in patients with JAK/STAT and PHF6 comutation than that in other patients, suggesting a potential role of PHF6 in leukemia progression.

TET3 Promotes AML Growth and Epigenetically Regulates Glucose Metabolism and Leukemic Stem Cell Associated Pathways

[Leukemia] Investigators reported that the epigenetic factor, Ten-Eleven Translocation 3 (TET3) dioxygenase was overexpressed in acute myeloid leukemia (AML) patients and functionally validated human leukemic stem cells, and was required for leukemic growth by virtue of its regulation of glucose metabolism in AML cells.

CCT245718, a Dual FLT3/Aurora a Inhibitor Overcomes D835Y-Mediated Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia Cells

[British Journal of Cancer] The ability of CCT245718 to overcome TKD-mediated resistance was evaluated in a cell line-based model of drug resistance to Fms-like tyrosine kinase 3 (FLT3) inhibitors.

A STAT5B-CD9 Axis Determines Self-Renewal in Hematopoietic and Leukemic Stem Cells

[Blood] Scientists found STAT5B to be specifically activated in HSCs and leukemic stem cells, where it induced many genes associated with quiescence and self-renewal, including the surface marker CD9.

Whole-Genome Analysis of TET Dioxygenase Function in Regulatory T Cells

[EMBO Reports] Investigators used whole-genome analyses to show that the transcriptional program and epigenetic features of Treg cells were attenuated in the absence of Tet2 and Tet3.

Popular