Scientists investigated the beneficial effects of endurance training on growth Associated Protein 43 (GAP-43) and Kinesin Family Member 5B (KIF5B) expression in gastrocnemius muscle of streptozotocin – induced diabetic rats.
we investigated the effects of neuron-specific Dynamin-related protein 1 deletion on synaptic damage and mitophagy in the hippocampus of a high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice.
[Cell Death & Disease]
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Park, G., Lee, J. Y., Han, H. M., An, H. S., Jin, Z., Jeong, E. A., Kim, K. E., Shin, H. J., Lee, J., Kang, D., Kim, H. J., Bae, Y. C., & Roh, G. S. (2021). Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death & Disease, 12(5), 1–15. https://doi.org/10.1038/s41419-021-03723-7 Cite
Researchers suggest that KCNQ1OT1 and its target gene miR-181a-5p regulated myocardial inflammation and cardiomyocyte apoptosis by modulating PDCD4 in diabetic cardiomyopathy.
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Long non-coding RNA KCNQ1OT1 increases the expression of PDCD4 by targeting miR-181a-5p, contributing to cardiomyocyte apoptosis in diabetic cardiomyopathy | SpringerLink. (n.d.). Retrieved May 3, 2021, from https://link.springer.com/article/10.1007%2Fs00592-021-01713-x Cite
Scientists investigated through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii yeast on the liver of streptozotocin induced diabetic C57BL/6 mice.
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Barssotti, L., Abreu, I. C. M. E., Brandão, A. B. P., Albuquerque, R. C. M. F., Ferreira, F. G., Salgado, M. A. C., Dias, D. D. S., De Angelis, K., Yokota, R., Casarini, D. E., Souza, L. B., Taddei, C. R., & Cunha, T. S. (2021). Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice. Scientific Reports, 11(1), 9189. https://doi.org/10.1038/s41598-021-88497-w Cite
Investigators observed β-cell dedifferentiation in type 2 diabetes mellitus and investigated the reversal effect of umbilical cord-derived MSCs on early- and late-stage β-cell dedifferentiation.
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Researchers hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females, despite any apparent sex differences in post-stroke brain injury.
[Stroke and Vascular Neurology]
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Nalamolu, K. R., Chelluboina, B., Fornal, C. A., Challa, S. R., Pinson, D. M., Wang, D. Z., Klopfenstein, J. D., & Veeravalli, K. K. (2021). Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke and Vascular Neurology, svn. https://doi.org/10.1136/svn-2020-000834 Cite
The authors assessed the therapeutic potential of co-administration of human clonal mesenchymal stem cells and liraglutide as a glucagon-like peptide-1 agonist in a non-human primate model with streptozotocin-induced diabetes.
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Navabi, R., Negahdari, B., Hajizadeh-Saffar, E., Hajinasrollah, M., Jenab, Y., Rabbani, S., Pakzad, M., Hassani, S.-N., Hezavehei, M., Jafari-Atrabi, M., Tahamtani, Y., & Baharvand, H. (2021). Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model. Life Sciences, 119374. https://doi.org/10.1016/j.lfs.2021.119374 Cite
Scientists explored possible roles of βA3/A1-crystallin in metabolism of retinal astrocytes. They found that βA1-crystallin acted as an uncompetitive inhibitor of protein tyrosine phosphatase 1B (PTP1B), but βA3-crystallin did not.
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Ghosh, S., Liu, H., Yazdankhah, M., Stepicheva, N., Shang, P., Vaidya, T., Hose, S., Gupta, U., Calderon, M. J., Hu, M.-W., Nair, A. P., Weiss, J., Fitting, C. S., Bhutto, I. A., Gadde, S. G. K., Naik, N. K., Jaydev, C., Lutty, G. A., Handa, J. T., … Sinha, D. (2021). βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity. Communications Biology, 4(1), 1–19. https://doi.org/10.1038/s42003-021-01763-5 Cite
Mesenchymal stromal/stem cells (MSCs) were studied in direct contact and indirect contact with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin in vitro.
[Stem Cell Research & Therapy]
Researchers determined the precise role of miR-34a in mesenchymal stem cells exposed to hyperglycaemia and in recovery heart function after myocardial infarction in diabetes mellitus rats.
[Stem Cell Research & Therapy]
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Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
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