The Effects of Exercise Training on Kinesin and GAP-43 Expression in Skeletal Muscle Fibers of STZ-Induced Diabetic Rats

Scientists investigated the beneficial effects of endurance training on growth Associated Protein 43 (GAP-43) and Kinesin Family Member 5B (KIF5B) expression in gastrocnemius muscle of streptozotocin – induced diabetic rats.
[Scientific Reports]
Rahmati, M., & Taherabadi, S. J. (2021). The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats. Scientific Reports, 11(1), 9535. https://doi.org/10.1038/s41598-021-89106-6 Cite
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Ablation of Dynamin-Related Protein 1 Promotes Diabetes-Induced Synaptic Injury in the Hippocampus

we investigated the effects of neuron-specific Dynamin-related protein 1 deletion on synaptic damage and mitophagy in the hippocampus of a high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice.
[Cell Death & Disease]
Park, G., Lee, J. Y., Han, H. M., An, H. S., Jin, Z., Jeong, E. A., Kim, K. E., Shin, H. J., Lee, J., Kang, D., Kim, H. J., Bae, Y. C., & Roh, G. S. (2021). Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death & Disease, 12(5), 1–15. https://doi.org/10.1038/s41419-021-03723-7 Cite
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Long Non-Coding RNA KCNQ1OT1 Increases the Expression of PDCD4 by Targeting miR-181a-5p, Contributing to Cardiomyocyte Apoptosis in Diabetic Cardiomyopathy

Researchers suggest that KCNQ1OT1 and its target gene miR-181a-5p regulated myocardial inflammation and cardiomyocyte apoptosis by modulating PDCD4 in diabetic cardiomyopathy.
[Acta Diabetologica]
Long non-coding RNA KCNQ1OT1 increases the expression of PDCD4 by targeting miR-181a-5p, contributing to cardiomyocyte apoptosis in diabetic cardiomyopathy | SpringerLink. (n.d.). Retrieved May 3, 2021, from https://link.springer.com/article/10.1007%2Fs00592-021-01713-x Cite
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Saccharomyces boulardii Modulates Oxidative Stress and Renin Angiotensin System Attenuating Diabetes-Induced Liver Injury in Mice

Scientists investigated through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii yeast on the liver of streptozotocin induced diabetic C57BL/6 mice.
[Scientific Reports]
Barssotti, L., Abreu, I. C. M. E., Brandão, A. B. P., Albuquerque, R. C. M. F., Ferreira, F. G., Salgado, M. A. C., Dias, D. D. S., De Angelis, K., Yokota, R., Casarini, D. E., Souza, L. B., Taddei, C. R., & Cunha, T. S. (2021). Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice. Scientific Reports, 11(1), 9189. https://doi.org/10.1038/s41598-021-88497-w Cite
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Reversion of Early- and Late-Stage β-Cell Dedifferentiation by Human Umbilical Cord-Derived Mesenchymal Stem Cells in Type 2 Diabetic Mice

Investigators observed β-cell dedifferentiation in type 2 diabetes mellitus and investigated the reversal effect of umbilical cord-derived MSCs on early- and late-stage β-cell dedifferentiation.
[Cytotherapy]
Li, B., Cheng, Y., Yin, Y., Xue, J., Yu, S., Gao, J., Liu, J., Zang, L., & Mu, Y. (2021). Reversion of early- and late-stage β-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.005 Cite
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Stem Cell Treatment Improves Post Stroke Neurological Outcomes: A Comparative Study in Male and Female Rats

Researchers hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females, despite any apparent sex differences in post-stroke brain injury.
[Stroke and Vascular Neurology]
Nalamolu, K. R., Chelluboina, B., Fornal, C. A., Challa, S. R., Pinson, D. M., Wang, D. Z., Klopfenstein, J. D., & Veeravalli, K. K. (2021). Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke and Vascular Neurology, svn. https://doi.org/10.1136/svn-2020-000834 Cite
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Combined Therapy of Mesenchymal Stem Cells with a GLP-1 Receptor Agonist, Liraglutide, on an Inflammatory-Mediated Diabetic Non-Human Primate Model

The authors assessed the therapeutic potential of co-administration of human clonal mesenchymal stem cells and liraglutide as a glucagon-like peptide-1 agonist in a non-human primate model with streptozotocin-induced diabetes.
[Life Sciences]
Navabi, R., Negahdari, B., Hajizadeh-Saffar, E., Hajinasrollah, M., Jenab, Y., Rabbani, S., Pakzad, M., Hassani, S.-N., Hezavehei, M., Jafari-Atrabi, M., Tahamtani, Y., & Baharvand, H. (2021). Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model. Life Sciences, 119374. https://doi.org/10.1016/j.lfs.2021.119374 Cite
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βA1-Crystallin Regulates Glucose Metabolism and Mitochondrial Function in Mouse Retinal Astrocytes by Modulating PTP1B Activity

Scientists explored possible roles of βA3/A1-crystallin in metabolism of retinal astrocytes. They found that βA1-crystallin acted as an uncompetitive inhibitor of protein tyrosine phosphatase 1B (PTP1B), but βA3-crystallin did not.
[Communications Biology]
Ghosh, S., Liu, H., Yazdankhah, M., Stepicheva, N., Shang, P., Vaidya, T., Hose, S., Gupta, U., Calderon, M. J., Hu, M.-W., Nair, A. P., Weiss, J., Fitting, C. S., Bhutto, I. A., Gadde, S. G. K., Naik, N. K., Jaydev, C., Lutty, G. A., Handa, J. T., … Sinha, D. (2021). βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity. Communications Biology, 4(1), 1–19. https://doi.org/10.1038/s42003-021-01763-5 Cite
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Intrapancreatic MSC Transplantation Facilitates Pancreatic Islet Regeneration

Mesenchymal stromal/stem cells (MSCs) were studied in direct contact and indirect contact with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin in vitro.
[Stem Cell Research & Therapy]
Khatri, R., Petry, S. F., & Linn, T. (2021). Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration. Stem Cell Research & Therapy, 12(1), 121. https://doi.org/10.1186/s13287-021-02173-4 Cite
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MiR-34a Inhibitor Protects Mesenchymal Stem Cells from Hyperglycaemic Injury through the Activation of the SIRT1/FoxO3a Autophagy Pathway

Researchers determined the precise role of miR-34a in mesenchymal stem cells exposed to hyperglycaemia and in recovery heart function after myocardial infarction in diabetes mellitus rats.
[Stem Cell Research & Therapy]
Zhang, F., Gao, F., Wang, K., Liu, X., & Zhang, Z. (2021). MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway. Stem Cell Research & Therapy, 12(1), 115. https://doi.org/10.1186/s13287-021-02183-2 Cite
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Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes

Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
[Antioxidants]
Zhang, J., Anshul, F., Malhotra, D. K., Jaume, J., Dworkin, L. D., & Gong, R. (2021). Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes. Antioxidants, 10(1), 138. https://doi.org/10.3390/antiox10010138 Cite
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