Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The authors suggested the observed therapeutic effect of lentiviral vector carrying vasoactive intestinal peptide(VIP) gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
[Gene Therapy]
Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The authors suggest the observed therapeutic effect of lentiviral vector carrying VIP gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
[Gene Therapy]
Abstract

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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The therapeutic efficacy of LentiVIP was tested in a multiple low-dose STZ-induced animal model of type 1 diabetes. LentiVIP delivery into diabetic animals reduced hyperglycemia, improved glucose tolerance, and prevented weight loss.
[Gene Therapy]
Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
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