Sox2

[Stem Cell Research] Natural killer cells were isolated from human umbilical cord blood from a healthy newborn and reprogrammed by episomal vectors carrying reprograming factors L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53 delivered using nucleofection.

[Stem Cells and Development] Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.

[iScience] The authors investigated whether ESCs retained memory of their previous states or transition in a memoryless (Markovian) process, and showed that some highly dynamic lineages of ESCs did not exhibit the Markovian property: their previous states and kin relations influenced future choices.

[Reproductive Toxicology] The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.

[Cell Reports] Scientists found that the Lin28 paralogs, which regulated post-transcriptional processing of both mRNAs and microRNAs, predominantly controlled mRNAs during the initial phases of lung organogenesis.

[Scientific Reports] The authors demonstrated that FOSL1 directly regulated four transcription factors bond to their promoter regions, was involved in the deregulation of several stemness markers, and reduced the cells’ ability to generate aggregates increasing the extracellular matrix component FN1.