Sox2

[Signal Transduction and Targeted Therapy] Researchers showed that ten–eleven translocation (TET) 2 loss associated with glioblastoma (GBM) stem cells and correlated with poor survival of GBM patients.

[Molecular Therapy-Methods & Clinical Development] Scientists inserted iCasp9 gene into the endogenous OCT4 locus of human and mouse PSCs without affecting their pluripotency. A chemical inducer of dimerization, AP1903, induced iCasp9 activation, which led to the apoptosis of specific undifferentiated PSCs in vitro and in vivo.

[Frontiers in Bioscience-Landmark] Using flow cytometry and western blot assays, the authors have demonstrated that programmed cell death ligand 1 expression is higher in endometrial cancer stem-like cell derived from endometrial cancer than in nonstem-like cancer cells.

[Stem Cells International] Researchers explored whether Mesenchymal stem cell- (MSC-) derived extracellular vesicles-delivered lipocalin-type prostaglandin D2 synthase (L-PGDS) could inhibit gastric cancer progression.

[Nature Communications] The authors developed an adenine base editor-based strategy to systematically identify functional m6A sites that controlled lineage decisions of human #ESCs.

[Toxicology and Applied Pharmacology] Researchers used Kaempferol in combination with Verapamil, in multiple assays to determine if there was an inhibitory effect on breast cancer stem cells.