Sox2

[Experimental Neurology] A Bergmann glia population was analyzed in the adult cerebellum of different species and showed conservation of neural stem cell-associated marker expression including Sox1, Sox2 and Sox9, in chick, primate and mouse cerebellum tissue.

[Skin Pharmacology and Physiology] Scientists assessed the effect of metformin on hair growth in a mouse hair follicle reconstitution model generated by in vitro self-assembled 3D aggregates of epidermal and dermal cells and suggested that metformin could promote hair follicle regeneration through up-regulation of the hair inductive capability of dermal cells.

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

[Stem Cell Research] The authors generated an iPSC line from the skin fibroblasts collected from a healthy 50-year old male donor. This model that could be used to model physiological processes and screen drug validation in vitro.

[Inflammation Research] miR-342-3p overexpression in LCSC lead to lower tumor volume, reduced tumor spheroid formation and agar colony formation rates, as well as lower mRNA and protein expressions of CD44, ALDH1, Bmi1, Sox2, and Oct4.

[Molecular Therapy-Methods & Clinical Development] Using Measles reprogramming vectors, researchers presented microRNA-targeting of exogenous OCT4 to shut down its expression during the mesenchymal to the epithelial transition phase of reprogramming.