Sox2

[Scientific Reports] Investigators generated cerebral organoids derived from human iPSCs (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.

[International Journal of Cancer] Investigators applied droplet-based single-cell RNA sequencing (scRNA-seq) to acquire transcriptional profiles of 36 619 single cells isolated from seven patients.

[Science Advances] The authors reported the ATP-binding cassette subfamily F member 1 (ABCF1) as a coactivator for OCT4/SOX2 critical for stem cell self-renewal.

[Oncogene] Scientists used a DNA-methylation pattern approach and uncovered evidence regarding the cell of origin of classical virus-associated merkel cell carcinomas (MCC) and virus-negative MCCs that were driven by UV-light-induced mutation cell lines, ie, cell lines with a neuroendocrine growth pattern.

[Journal of Translational Medicine] The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.

[Cell Death & Disease] Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes