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T-cell leukemia

SCAMP2/5 as Diagnostic and Prognostic Markers for Acute Myeloid Leukemia

[Scientific Reports] The authors explored expression patterns and prognostic value of secretory carrier-associated membrane proteins (SCAMPs) and network analysis of SCAMPs-related signaling pathways in acute myeloid leukemia using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases.

Chronological Genome and Single-Cell Transcriptome Integration Characterizes the Evolutionary Process of Adult T Cell Leukemia-Lymphoma

[Nature Communications] Scientists developed and utilized a capture-based sequencing panel, which covered host hotspot genes and the full-length genome of human T-cell leukemia virus type-1, to investigate the clonal architecture of adult T-cell leukemia-lymphoma.

The Requirement for Pyruvate Dehydrogenase in Leukemogenesis Depends on Cell Lineage

[Cell Metabolism] Investigators compared glucose metabolism in hematopoiesis and leukemia. Thymus T cell progenitors were glucose avid and oxidized more glucose in the tricarboxylic acid cycle through pyruvate dehydrogenase as compared with other hematopoietic cells.

Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

[Cancer Research] In vitro treatment of Idh2R140Q/NHD13 thymocytes with enasidenib, a selective inhibitor of mutant IDH2, led to a marked decrease in leukemic cell proliferation, demonstrating that Idh2R140Q/NHD13 mice could serve as a useful in vivo model for the study of early/immature T cell precursor acute lymphoid leukemia (ALL) development and therapy.

Single-Cell Chromatin Accessibility Landscape of Human Umbilical Cord Blood in Trisomy 18 Syndrome

[Human Genomics] Scientists used the commercial Chromium platform to perform sc-ATAC-seq to measure chromatin accessibility in 11,611 single umbilical cord blood cells derived from one trisomy 18 syndrome patient and one healthy donor.

AAV-Mediated In Vivo CAR Gene Therapy for Targeting Human T-Cell Leukemia

[Blood Cancer Journal] Investigators described a novel approach in which human chimeric antigen receptor (CAR T) cells could be generated within the host upon injecting an adeno-associated virus (AAV) vector carrying the CAR gene, which they called AAV delivering CAR gene therapy.

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