T cells

[Frontiers in Immunology] The authors explored the combination between zeste homolog 2 (EZH2) inhibitor and an agonist antibody targeting the T cell costimulatory receptor 4-1BB.

[Journal of Immunology] Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), the authors produced CD8+ CAR T cells that target CD4+ T cells in an Ag-specific manner and tested their ability to inhibit the development of autoimmune arthritis in a mouse model.

[Todos Medical, Ltd.] Todos Medical, Ltd. announced that it has entered into an exclusive European licensing & distribution agreement with T Cell Protect Hellas S.A. for a product based on its Tollovid® and Tollovid Daily™ 3CL protease inhibitor and immune support dietary supplements.

[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)] Cytovia Therapeutics, Inc. and Cellectis announced that they have expanded their collaboration of TALEN® gene-edited iPSC-derived natural killer (NK) and chimeric antigen receptor (CAR)-NK cells to include new CAR target and development in China by Cytovia’s joint venture entity, CytoLynx Therapeutics.

[Journal of Clinical Investigation] Using barcoded pMHC multimers, scientists provided a comprehensive mapping of CD8+ T cells recognizing neoepitopes in Tumor-Infiltrating Lymphocyte infusion products and blood samples from 26 metastatic mela-noma patients who received adoptive cell therapy.

[Journal of Clinical Investigation] Using single-cell RNA sequencing and paired TCRα/β sequencing, researchers assessed the transcriptomes of CD154+ and CD137+ peanut-reactive T helper cells from 12 peanut-allergic patients longitudinally throughout oral immunotherapy.