T cells

[Nature Communications] Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Researchers found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.

[Cell Research] MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps, and promoted the maintenance of SARS-CoV-2-specific antibodies.

[Cytotherapy] The authors provided a platform for identifying markers for predicting MSC functional capacity using partial least squares regression modeling that could be used as release criteria and guide future manufacturing strategies for mesenchymal stromal cells and other cell therapies.

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Cell Death & Disease] Researchers showed that high LSD1 expression was a predictor of poor prognosis for head and neck squamous cell carcinoma patients. They found that high expression of LSD1 was essential for the maintenance of the CSC properties by regulating Bmi-1 expression.

[Pharmacotherapy] Investigators examined the pharmacokinetics and pharmacodynamics of alemtuzumab in adults with sickle cell disease who received a matched related donor hematopoietic stem cell transplant and determined if the clearance of alemtuzumab affected transplant outcomes.