T cells

[Science Immunology] Scientists demonstrated that engagement of the innate immune system following SARS-CoV-2 infection was delayed but was followed by a pronounced adaptive response.

[Cancer Cell] Researchers demonstrated that murine and human T helper (Th) 9 cells, but not Th1/Tc1 or Th17 cells, expressing tumor-specific T cell receptors or CARs, eradicated advanced tumors that contained antigen-loss-variant.

[Molecular Therapy] To reprogram the functional capacities specifically of engineered CAR T cells, the authors inserted IL12 into the extracellular moiety of a CD28-ζ CAR.

[Nature Nanotechnology] Investigators presented the design of light-switchable CAR T cells that allowed real-time phototunable activation of therapeutic T cells to precisely induce tumor cell killing.

[Leukemia & Lymphoma] Researchers investigated the efficiency and prognostic role of cytoplasmic CD79a antibody-gated multicolor flow cytometry in minimal residual disease detection in patients with B-ALL who received CD19-targeted chimeric antigen receptor (CAR) T-cell therapy bridging to allogeneic hematopoietic stem cell transplantation.

[Molecular Therapy] Investigators discuss gene editing approaches that have been the best studied in the context of human T cells and adoptive T cell therapies, summarizing their current status and near-term potential for translation.