T cells

[eLife] The authors demonstrated that homology cluster analysis of T cell receptor (TCR) repertoires efficiently identified tumor-reactive TCRs.

[Nature Immunology] The authors utilize major histocompatibility complex multimers with single-cell RNA sequencing to profile SARS-CoV-2-responsive T cells ex vivo from humans with one, two or three antigen exposures, including vaccination, primary infection and breakthrough infection.

[Immunity] Scientists identified transcriptionally distinct exhausted T cell subpopulations, mapped their differentiation trajectories via transitory cellular states toward exhausted CD8+ T cells, and localized these cell states to specific splenic niches.

[Cell Death & Disease] The authors observed the downregulation of senescence-related genes by adoptive infusion of NK cells in 26 cases in peripheral blood CD3+ T cells.

[Journal of Experimental Medicine] Researchers explored the role of miRNAs in the pathogenesis of inflammatory bowel disease (IBD) and identified reduced expression of miR-374a-5p in IBD monocytes that correlated with a module of up-regulated genes related to the inflammatory response.

[Clinical infectious Diseases] Researchers investigated SARS-CoV-2 vaccine immunogenicity in PLWH according to current CD4 T-cell count.