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T cells

PD-1 Inhibition in Advanced Myeloproliferative Neoplasms

[Blood Advances] Investigators conducted a multicenter, open-label, Phase II, single-arm study of pembrolizumab in patients with DIPSS intermediate 2 or greater primary, post-essential thrombocythemia or post-polycythemia vera myelofibrosis that were ineligible for or were previously treated with ruxolitinib.

Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells

[Frontiers in Immunology] Scientists describe basic knowledge of T cell biology, applications in adoptive cell therapy, the use of iPSCs as a new source of T cells and current differentiation strategies used to generate T cells as well as recent advances in genome engineering to produce next-generation off-the-shelf T cells with improved effector functions.

ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

[Cancer Research] Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.

Metabolomics Activity Screening of T Cell–Induced Colitis Reveals Anti-Inflammatory Metabolites

[Science Signaling] Investigators used the T cell transfer mouse model of colitis to identify small-molecule metabolites with altered abundance due to intestinal inflammation.

BTN2A2 Protein Negatively Regulates T Cells to Ameliorate Collagen-Induced Arthritis in Mice

[Scientific Reports] Researchers investigated the ability of a recombinant BTN2A2-IgG2a Fc fusion protein to treat Collagen type II (CIA). They showed that administration of BTN2A2-Ig attenuatex established CIA, as compared with control Ig protein treatment.

Dynamics of TCR Repertoire and T Cell Function in COVID-19 Convalescent Individuals

[Cell Discovery] The authors presented both single-cell TCR-seq and RNA-seq to analyze the dynamics of TCR repertoire and immune metabolic functions of blood T cells collected from recently discharged COVID-19 patients.

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