T cells

[Scientific Reports] The authors investigated the effect of Trastuzumab deruxtecan on the expression of HLA class I and CXCL9/10/11, T cell chemoattractants, in HER2-positive human gastric cancer cells.

[Immunity] Scientists examined the role of CCL1 in pulmonary fibrosis (PF). Bronchoalveolar lavage fluid from PF mouse models contained high amounts of CCL1, as did lung biopsies from PF patients.

[Molecular Carcinogenesis] Scientists showed that methylseleninic acid substantially attenuated cisplatin-induced PD-L1 expression via inhibiting protein kinase B phosphorylation, thereby potentiated cisplatin cytotoxicity in prostate and lung cancer cell models.

[Cell Host & Microbe] Researchers identified gut bacteria that synthesized isoalloLCA from 3-oxolithocholic acid and uncovered a gene cluster responsible for the conversion in members of the abundant human gut bacterial phylum Bacteroidetes.

[Nature Communications] The authors reported a stromal cell-free, microbead-based approach that supported the efficient in vitro development of both human progenitor T cells and T-lineage cells from CD34+ cells sourced from cord blood, GCSF-mobilized peripheral blood, and PSCs.

[Molecular Oncology] Transcriptome analyses indicated that chronic estrogen receptor alpha (ERα) inhibition triggered a broad immunosuppressive program in ER-positive breast cancer cells, which was subsequent to their growth arrest and involved the activation of multiple immune checkpoints together with the silencing of the antigen presentation machinery.