T cells

[Leukemia] The increased stemness of acute myeloid leukemia (AML) cells promoted by Tregs was verified in vitro and in vivo, and researchers found that blocking the interaction between Tregs and AML cells may be a new approach to target leukemia stem cells in AML treatment.

[Oncogene] Scientists demonstrated that mutations in the adenomatous polyposis coli (APC) gene led to colonic epithelial cell resistance to CD8+ T cell cytotoxicity by induction of PD-L1 expression.

[eLife] Scientists established two murine Ebf1-deficient pro-B cell lines, with and without T-lineage potential. The latter expressed lower levels of Lmo2; their potential was restored via ectopic expression of Lmo2.

[Journal of Biological Chemistry] Scientists showed that cellular communication of exosomal TNF-α from Huh-7 regulatesdosteoclast differentiation through NF-κB/CTSK/TRAP expressions.

[Science Translational Medicine] Investigators found that antiangiogenic treatment facilitated non–small cell lung cancer tumor infiltration by PD-1+ regulatory T cells, which were more efficiently targeted by the PD-1 antibody than CD8+ T cells.

[Nature Biomedical Engineering] In mice with subcutaneous tumors, locally injected T cells with the inducible CAR and activated via focused ultrasound guided by magnetic resonance imaging mitigated on-target off-tumor activity and enhanced the suppression of tumor growth, compared with the performance of non-inducible CAR-T cells.