T cells

[Journal of Clinical Investigation] Starting with the observation that T cells moved more quickly through mouse tumors as residence time increased and they progressed towards exhaustion, the authors elaborated a non-stimulatory live-biopsy method for real-time study of T cell behaviors within individual patient tumors.

[Journal of Experimental Medicine] Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.

[Blood] Researchers introduced sialic-acid-binding immunoglobulin-like lectin (Siglec)-6 as a novel target for CAR T-cells in acute myeloid leukemia (AML) and found that Siglec-6 was prevalently expressed on AML cell lines and primary AML blasts, including the subpopulation of AML stem cells.

[Nature Communications] Scientists reported that 3-hydroxy-L-kynurenamine was a biogenic amine produced via an alternative pathway of tryptophan metabolism.

[Nature Communications] Researchers described a human CD137xPD-L1 bispecific antibody, MCLA-145, identified through functional screening of agonist- and immune checkpoint inhibitor arm combinations.

[Oncogene] The authors summarize how T cell activation is controlled by dendritic cells and how the tumor microenvironment alters dendritic cell properties in the context of the anti-tumor immune cycle.