T cells

[Journal of Clinical Investigation] In mice, lack of PTPN22 augmented antitumor activity with greater infiltration and activation of macrophages, natural killer (NK) cells, and T cells.

[Science Signaling] Increasing or decreasing Syk activity by stimulating the γδ T cell receptor (TCRγδ) or inhibiting Syk, respectively, substantially reduced γδ17 cell numbers.

[Scientific Reports] The authors demonstrated subcutaneous prime and SC boost vaccination of CD-1 mice with this dual-antigen vaccine elicits T-helper cell 1 biased T-cell and humoral responses to both spike (S) and nucleocapsid (N) that were greater than those seen with hAd5 S wild type delivering only unmodified S.

[Nature] Scientists showed, by linking the antigenic specificity of TCRs and the cellular phenotype of melanoma-infiltrating lymphocytes at single-cell resolution, that tumor specificity shaped the expression state of intratumoural CD8+ T cells.

[Nature] Scientists recast unconventional T cell subsets according to the class of ligand that they recognize; their expression of semi-invariant or diverse T cell receptors; the structural features that underlie ligand recognition; their acquisition of effector functions in the thymus or periphery; and their distinct functional properties.

[Biochimica et Biophysica Acta-Reviews On Cancer] Investigators review the current progress targeting different immune checkpoints in several-lines treatment for TNBC, including programmed death-1/programmed death ligand-1 inhibitors, cytotoxic T-lymphocyte associated antigen-4 inhibitor, and other novel immunotherapeutic approaches.