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T cells

BATF and IRF4 Cooperate to Counter Exhaustion in Tumor-Infiltrating CAR T Cells

[Nature Immunology] Overexpression of BATF in CD8+ T cells expressing a chimeric antigen receptor (CAR) promoted the survival and expansion of tumor-infiltrating CAR T cells, increased the production of effector cytokines, and decreased the expression of inhibitory receptors.

Alternative Pathways for the Development of Lymphoid Structures in Humans

[Proceedings of the National Academy of Sciences of the United States of America] In humans, JAK3 and γc deficiencies resulted in severe combined immunodeficiency characterized by an absence of T cells, natural killer cells, innate lymphoid cells, and presumably lymphoid tissue inducer cells.

Non-Terminally Exhausted Tumor-Resident Memory HBV-Specific T Cell Responses Correlate with Relapse-Free Survival in Hepatocellular Carcinoma

[Immunity] Using highly multiplexed peptide-MHC tetramer staining of unexpanded cells from blood, liver, and tumor tissues from 46 HCC patients, researchers detected 91 different antigen-specific CD8+ T cell populations targeting HBV, neoantigen, tumor-associated, and disease-unrelated antigens.

Adenovirus Vector Vaccination Reprograms Pulmonary Fibroblastic Niches to Support Protective Inflating Memory CD8+ T Cells

[Nature Immunology] The authors showed that clinically applied adenovirus vectors preferentially targeted fibroblastic stromal cells in cultured human tissues.

Single-Cell Transcriptome and TCR Profiling Reveal Activated and Expanded T Cell Populations in Parkinson’s Disease

[Cell Discovery] Scientists performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of Parkinson’s disease.

CD40 Stimulation as a Molecular Adjuvant for Cancer Vaccines and Other Immunotherapies

[Cellular & Molecular Immunology] The rationale and early immunobiology of CD40 as a master regulator of dendritic cell activation is reviewed, with further contextualization and appreciation for the role of CD40 stimulation not only in cancer vaccines but also in other contemporary immune-oncology approaches.

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