T cells

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Direct exposure of colonic epithelial organoids to dextran sulfate sodium, oxazolone, or TNBS resulted in increased apoptosis and loss of Lgr5+ cells. Targeted ablation of Lgr5+ cells resulted in severe exacerbation of chronic, antibody-induced IL-10-deficient colitis, but had only modest effects in TNBS-induced colitis.

[Nature Communications] The authors provided evidence that the SUMO protease SENP1 promoted T cell memory development via Sirt3 deSUMOylation. SENP1-Sirt3 signaling augmented the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion.

[Cancer Research] Investigators showed that inhibition of the hyperactive mevalonate (MVA) metabolic pathway in tumor cells elicited type 1 classical dendritic cells-mediated tumor recognition and antigen cross-presentation for antitumor immunity.

[Genes & Development] At the earliest stages of T cell development, cells with random chromosome gains and/or losses were selected against, but chromosomal instability eventually resulted in the expansion of progenitors with clonal chromosomal imbalances.

[Stroke] Lymphocytes from Nur77GFP transgenic mice express a fluorescent protein upon activation via the TCR, allowing the differentiation of activation mode in a natural repertoire of immune cells and antigens.

[Trends in Immunology] Investigators summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.