Mycobacterium tuberculosis-Specific CD4 T Cells Expressing CD153 Inversely Associate with Bacterial Load and Disease Severity in Human Tuberculosis

Investigators showed that the proportion of Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 was significantly reduced in active tuberculosis patients compared to latently infected persons.
[Mucosal Immunology]
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Tumor Response and Endogenous Immune Reactivity after Administration of HER2 CAR T Cells in a Child with Metastatic Rhabdomyosarcoma

Longitudinal immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway proteins.
[Nature Communications]
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Ageing Hallmarks Exhibit Organ-Specific Temporal Signatures

Researchers performed bulk RNA sequencing of 17 organs and plasma proteomics at ten ages across the lifespan of Mus musculus, and integrated these findings with data from the accompanying Tabula Muris Senis—or ‘Mouse Ageing Cell Atlas’—which followed on from the original Tabula Muris.
[Nature]
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Precision Installation of a Highly Efficient Suicide Gene Safety Switch in Human Induced Pluripotent Stem Cells

Investigators report that the commonly used EF1α promoter was silenced in induced pluripotent stem cells, and that the endogenous promoter of the PPP1R12C gene was not strong enough to drive high levels of inducible caspase‐9 expression.
[Stem Cells Translational Medicine]
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CD73 Acts as a Prognostic Biomarker and Promotes Progression and Immune Escape in Pancreatic Cancer

Investigators found that the expression of CD73 was up‐regulated in pancreatic cancer tissues and patients with higher CD73 expression had poorer overall survival and disease‐free survival in multiple publicly available databases.
[Journal of Cellular and Molecular Medicine]
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Effect of Gemcitabine Based Chemotherapy on the Immunogenicity of Pancreatic Tumor Cells and T-Cells

Pancreatic tumor cell lines were stimulated with the chemotherapeutic agents and markers of immune recognition were assessed.
[Clinical and Translational Oncology]
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Tissue-Resident Memory CD8+ T Cells Shape Local and Systemic Secondary T Cell Responses

Investigators developed a unique lineage tracer mouse model exploiting the tissue-resident memory CD8+ T cells (TRM)-defining transcription factor homolog of Blimp-1 in T cells to fate map the TRM progeny in secondary responses.
[Nature Immunology]
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HIV-2-Infected Macrophages Produce and Accumulate Poorly Infectious Viral Particles

Researchers studied the relationship between macrophages and HIV-2, focusing on post-entry steps. HIV-2-infected monocyte-derived macrophages produced substantial amounts of viral particles that were largely harbored intracellularly.
[Frontiers in Microbiology]
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The Interplay between Innate Lymphoid Cells and T Cells

Scientists discuss the diversity of functional interactions between T cells and ILCs during homeostasis and immune responses.
[Mucosal Immunology]
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Dynamic Palmitoylation Events following T-cell Receptor Signaling

Following stimulation of the T-cell receptor scientists found a number of proteins were newly palmitoylated, including those involved in vesicle-mediated transport and Ras signal transduction.
[Communications Biology]
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Regulatory T Cells for Treating Patients with COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports

Physician-investigators at Johns Hopkins University Hospital report on the promising data of treatment of COVID-19 induced acute respiratory distress syndrome with allogeneic, cord blood derived T-regulatory cell therapy.
[Annals of Internal Medicine]
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