Host rejection driven by HLA disparity in adoptively transferred allogeneic T cells remains a key obstacle to the universal donor T cell therapy. To evade donor HLA-mediated immune rejection, scientists attempted to eliminate T cell’s HLA through the CRISPR/Cas9 gene editing system.
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Using single-cell RNA sequencing, researchers characterized the peripheral blood mononuclear cells from uninfected controls and COVID-19 patients and cells in paired broncho-alveolar lavage fluid.
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The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing | Cell Discovery. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41421-020-00225-2 Cite
Using mass cytometry, scientists uncovered a naive CD8+ T cell population expressing CD95 that was enriched in patients with high compared with low cardiovascular disease.
[Arteriosclerosis Thrombosis and Vascular Biology]
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Padgett Lindsey E., Dinh Huy Q., Wu Runpei, Gaddis Dalia E., Araujo Daniel J., Winkels Holger, Nguyen Anh, McNamara Coleen A., & Hedrick Catherine C. (n.d.). Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity. Arteriosclerosis, Thrombosis, and Vascular Biology, 0(0), ATVBAHA.120.315106. https://doi.org/10.1161/ATVBAHA.120.315106 Cite
Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.
Scientists showed that a highly conserved NFAT binding site within the distal noncoding element hHS-8 coordinately controlled TNF and LTA gene expression in human T cells.
[Journal of Immunology]
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Jasenosky, L. D., Nambu, A., Tsytsykova, A. V., Ranjbar, S., Haridas, V., Kruidenier, L., Tough, D. F., & Goldfeld, A. E. (2020). Identification of a Distal Locus Enhancer Element That Controls Cell Type–Specific TNF and LTA Gene Expression in Human T Cells. The Journal of Immunology, 205(9), 2479–2488. https://doi.org/10.4049/jimmunol.1901311 Cite
Scientists compare and contrast the T cell tolerance checkpoints and discuss their specific roles, with the aim of providing an integrated view of T cell peripheral tolerance and fate regulation.
[Nature Reviews Immunology]
Scientists compared transplantation of human CD34+ HSPCs purified from three different sources: umbilical cord blood, adult bone marrow, and adult G-CSF mobilized peripheral blood.
[Frontiers in Immunology]
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A newly-designed water-soluble far-red emitting polymer probe, 19K-6H, with a large Stokes shift, was thus evaluated for the tracking of primary immune CD8 T cells. 19K-6H-labelled primary CD8 T cells were injected to mice in a classical model of immune mediated hepatitis.
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Multiscale fluorescent tracking of immune cells in the liver with a highly biocompatible far-red emitting polymer probe | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-74621-9 Cite
Forty-three subjects with B-cell acute lymphoblastic leukemia relapsing post allotransplant received CAR-T cells were analyzed.
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Zhang, C., Wang, X.-Q., Zhang, R.-L., Liu, F., Wang, Y., Yan, Z.-L., Song, Y.-P., Yang, T., Li, P., Wang, Z., Ma, Y.-Y., Gao, L., Liu, Y., Gao, L., Kong, P.-Y., Liu, J., Tan, X., Zhong, J. F., Chen, Y.-Q., … Zhang, X. (2020). Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant. Leukemia, 1–8. https://doi.org/10.1038/s41375-020-01056-6 Cite
Midkine was found to control the transcriptome of melanoma cells, allowing for coordinated activation of nuclear factor-κB and downregulation of interferon-associated pathways.
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Cerezo-Wallis, D., Contreras-Alcalde, M., Troulé, K., Catena, X., Mucientes, C., Calvo, T. G., Cañón, E., Tejedo, C., Pennacchi, P. C., Hogan, S., Kölblinger, P., Tejero, H., Chen, A. X., Ibarz, N., Graña-Castro, O., Martinez, L., Muñoz, J., Ortiz-Romero, P., Rodriguez-Peralto, J. L., … Soengas, M. S. (2020). Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-020-1073-3 Cite
By generating Leukotriene B4 (LTB4)-producing enzyme LTA4H knockout mice and CD11c promoter-driven Cre recombinase-expressing BLT1 conditional knockout mice, researchers showed that the migration of BLT1hi dendritic cells exacerbated allergic contact dermatitis.
[Cellular & Molecular Immunology]
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Koga, T., Sasaki, F., Saeki, K., Tsuchiya, S., Okuno, T., Ohba, M., Ichiki, T., Iwamoto, S., Uzawa, H., Kitajima, K., Meno, C., Nakamura, E., Tada, N., Fukui, Y., Kikuta, J., Ishii, M., Sugimoto, Y., Nakao, M., & Yokomizo, T. (2020). Expression of leukotriene B 4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cellular & Molecular Immunology, 1–13. https://doi.org/10.1038/s41423-020-00559-7 Cite