Tag results:

T cells

A Guide to Antigen Processing and Presentation

[Nature Reviews Immunology] Scientists describe the essentials of antigen processing and presentation and how the source proteins for these antigens are tagged for degradation, destroyed and ultimately displayed as peptides in complex with major histocompatibility complex molecules for T cell recognition.

Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma

[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.

Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis

[Neurotherapeutics] Individuals with HIV-associated amyotrophic lateral sclerosis (ALS) show a remarkable response to antiretroviral therapy; however, antiretroviral trials in ALS down-regulate HML-2 without ameliorating the disease.

CAR T Cell Killing Requires the IFNγR Pathway in Solid but Not Liquid Tumours

[Nature] To systematically identify potential resistance pathways in an unbiased manner, scientists conducted a genome-wide CRISPR knockout screen in glioblastoma, a disease in which CAR T cells have had limited efficacy.

CDI Laboratory Secures NIH Funding for Thymus Immunotherapy Research

[NIH (Newswise, Inc.)] A new grant from the National Institutes of Health (NIH) and the National Cancer Institute will fund a physician-scientist from the Hackensack Meridian Center for Discovery and Innovation to investigate ways to harness the body’s natural ability to create CAR T cells for long-term treatment of pediatric blood cancers.

Menstrual Blood-Derived Mesenchymal Stromal Cells Efficiently Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting T Cell Activation in Mice

[Stem Cell Research & Therapy] Researchers evaluated the therapeutic potential of MSCs isolated from menstrual blood as ready-to-use allo-MSCs in multiple sclerosis by application in its animal model experimental autoimmune encephalomyelitis.