T cells

[Nature Medicine] Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.

[Proceedings of the National Academy of Sciences of the United States of America] A protease-activated prodrug form of the anti-mouse CD137 agonist antibody 1D8 was constructed and found to be selectively activated in the tumor microenvironment.

[Scientific Reports] Intravenously treating with single strain for three times, or with both strains alternately for three times significantly reduced the tumor size and prolonged the survival time of model mice.

[Journal of Cellular Physiology] Real-time cell migration analysis, measuring wound closure rates over 24 hours, revealed that 18αGA essentially blocked wound closure whereas hexokinase and GSK-7975A showed relatively minimal effects.

[Journal of Pathology] Using single cell RNA-sequencing, investigators identified and validated the in situ localization of three smooth muscle subtypes and two novel fibroblast subtypes in human prostate.

[Scientific Reports] Scientists established liver tumor cell lines from hepatitis C virus transgenic mice fed an atherogenic high-fat diet.