[Oncogene] Liver-specific overexpression of GRB2-associated-binding protein 2 (Gab2) mice accelerated hepatoma progression possibly through activating IL-6-initiated the activation of myeloid-derived suppressor cells.
[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.
[Proceedings of the National Academy of Sciences of the United States of America] The authors suggested that targeting lysophosphatidic acid (LPA) signaling in chronic inflammatory conditions may have rescued T cell function and promoted antiviral and antitumor immunity.
[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.
[Immunity] Researchers investigated the relative contribution of potential ligands, stable peptide-MHC class II complexes and fibrinogen-like protein 1, to lymphocyte activation gene-3 (LAG-3) activity in vitro and in vivo.
[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.