Tag Archives: T cells

A Clinically Applicable and Scalable Method To Regenerate T-Cells from iPSCs for Off-the-Shelf T-Cell Immunotherapy

Scientists showed improved differentiation efficiency of T-cells from induced PSCs (iPSCs) derived from an antigen-specific cytotoxic T-cell clone, or from T-cell receptor-transduced iPSCs, as starting materials.
[Nature Communications]
Iriguchi, S., Yasui, Y., Kawai, Y., Arima, S., Kunitomo, M., Sato, T., Ueda, T., Minagawa, A., Mishima, Y., Yanagawa, N., Baba, Y., Miyake, Y., Nakayama, K., Takiguchi, M., Shinohara, T., Nakatsura, T., Yasukawa, M., Kassai, Y., Hayashi, A., & Kaneko, S. (2021). A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy. Nature Communications, 12(1), 430. https://doi.org/10.1038/s41467-020-20658-3 Cite
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Human Intestinal Tissue-Resident Memory T Cells Comprise Transcriptionally and Functionally Distinct Subsets

Researchers investigated transcriptional and functional heterogeneity of human tissue-resident memory T (TRM) cells through study of donor-derived TRM cells from intestinal transplant recipients.
[Cell Reports]
FitzPatrick, M. E. B., Provine, N. M., Garner, L. C., Powell, K., Amini, A., Irwin, S. L., Ferry, H., Ambrose, T., Friend, P., Vrakas, G., Reddy, S., Soilleux, E., Klenerman, P., & Allan, P. J. (2021). Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Reports, 34(3). https://doi.org/10.1016/j.celrep.2020.108661 Cite
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Distinct Metabolic Programs Established in the Thymus Control Effector Functions of γδ T Cell Subsets in Tumor Microenvironments

Scientists found that γδ T cell subsets making either interferon-γ or interleukin-17 have intrinsically distinct metabolic requirements.
[Nature Immunology]
Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A. C., Fiala, G. J., Agudelo, L. Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M., Argüello, R. J., … Lynch, L. (2021). Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments. Nature Immunology, 1–14. https://doi.org/10.1038/s41590-020-00848-3 Cite
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Combining NanoKnife with M1 Oncolytic Virus Enhances Anticancer Activity in Pancreatic Cancer

Scientists evaluated improvements to therapeutic efficacy through combination therapy incorporating NanoKnife and M1 virus. They showed that irreversible electroporation triggered reactive oxygen species-dependent apoptosis in pancreatic cancer cells mediated by phosphatidylinositol-3-kinase/protein kinase B pathway suppression.
[Cancer Letters]
Sun, S., Liu, Y., He, C., Hu, W., Liu, W., Huang, X., Wu, J., Xie, F., Chen, C., Wang, J., Lin, Y., Zhu, W., Yan, G., Cai, J., & Li, S. (2021). Combining NanoKnife with M1 oncolytic virus enhances anticancer activity in pancreatic cancer. Cancer Letters, 502, 9–24. https://doi.org/10.1016/j.canlet.2020.12.018 Cite
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Heightened Resistance To Host Type 1 Interferons Characterizes HIV-1 at Transmission and After Antiretroviral Therapy Interruption

Researchers characterized the IFN-I sensitivity of 500 clonally derived HIV-1 isolates from the plasma and CD4+ T cells of 26 individuals sampled longitudinally after transmission or after antiretroviral therapy and analytical treatment interruption.
[Science Translational Medicine]
Gondim, M. V. P., Sherrill-Mix, S., Bibollet-Ruche, F., Russell, R. M., Trimboli, S., Smith, A. G., Li, Y., Liu, W., Avitto, A. N., DeVoto, J. C., Connell, J., Fenton-May, A. E., Pellegrino, P., Williams, I., Papasavvas, E., Lorenzi, J. C. C., Salantes, D. B., Mampe, F., Monroy, M. A., … Hahn, B. H. (2021). Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption. Science Translational Medicine, 13(576). https://doi.org/10.1126/scitranslmed.abd8179 Cite
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Low-Dose Decitabine Priming Endows CAR T Cells with Enhanced and Persistent Antitumor Potential via Epigenetic Reprogramming

Anti-tumor activities, cytokine production, and proliferation were enhanced in decitabine-treated chimeric antigen receptor T cells both in vitro and in vivo.
[Nature Communications]
Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming | Nature Communications. (n.d.). Retrieved January 18, 2021, from https://www.nature.com/articles/s41467-020-20696-x Cite
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Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy

Scientists analyzed the safety and evaluate preliminary efficacy of polyomavirus JC-specific T cell therapy in a cohort of hematological patients with Progressive Multifocal Leukoencephalopathy.
[Annals of Neurology]
Berzero, G., Basso, S., Stoppini, L., Palermo, A., Pichiecchio, A., Paoletti, M., Lucev, F., Gerevini, S., Rossi, A., Vegezzi, E., Diamanti, L., Bini, P., Gastaldi, M., Delbue, S., Perotti, C., Seminari, E., Faraci, M., Luppi, M., Baldanti, F., … Comoli, P. (n.d.). Adoptive transfer of JC virus-specific T lymphocytes for the treatment of Progressive Multifocal Leukoencephalopathy. Annals of Neurology, n/a(n/a). https://doi.org/https://doi.org/10.1002/ana.26020 Cite
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Gut CD4+ T Cell Phenotypes Are a Continuum Molded by Microbes, Not by TH Archetypes

To determine the states that CD4+ effector lymphocytes (Teff) cells actually adopt in frontline tissues in vivo, scientists applied single-cell transcriptome and chromatin analyses to colonic Teff cells in germ-free or conventional mice
[Nature Immunology]
Kiner, E., Willie, E., Vijaykumar, B., Chowdhary, K., Schmutz, H., Chandler, J., Schnell, A., Thakore, P. I., LeGros, G., Mostafavi, S., Mathis, D., & Benoist, C. (2021). Gut CD4 + T cell phenotypes are a continuum molded by microbes, not by T H archetypes. Nature Immunology, 1–13. https://doi.org/10.1038/s41590-020-00836-7 Cite
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Droplet-Based mRNA Sequencing of Fixed and Permeabilized Cells by CLInt-Seq Allows for Antigen-Specific TCR Cloning

Scientists applied CLInt-Seq to identify T cell receptors reactive with peptide epitopes of prostatic acid phosphatase, which has been pursued by multiple groups as an immunotherapeutic target in prostate cancer.
[Proceedings of the National Academy of Sciences of the United States of America]
Nesterenko, P. A., McLaughlin, J., Cheng, D., Bangayan, N. J., Sojo, G. B., Seet, C. S., Qin, Y., Mao, Z., Obusan, M. B., Phillips, J. W., & Witte, O. N. (2021). Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2021190118 Cite
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An Immunohistochemical Study of Lymphatic Elements in the Human Brain

Lymphatic marker-positive cells were present in the perivascular space, the walls of small and large arteries and veins, the media of large vessels along smooth muscle cell membranes, and the vascular adventitia.
[Proceedings of the National Academy of Sciences of the United States of America]
Mezey, É., Szalayova, I., Hogden, C. T., Brady, A., Dósa, Á., Sótonyi, P., & Palkovits, M. (2021). An immunohistochemical study of lymphatic elements in the human brain. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2002574118 Cite
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NantKwest, ImmunityBio Announce Positive Interim Data on Survival Rates in Metastatic Pancreatic Cancer Trials

NantKwest, Inc. and ImmunityBio, Inc. announced early interim results of its PD-L1 t-haNK protocols showing median survival rates more than doubled that of the historic rate in patients with advanced metastatic pancreatic cancer for which no other FDA-approved treatment exists.
[NantKwest, Inc.]
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