Differential Expression Profile of Gluten-Specific T Cells Identified by Single-Cell RNA-Seq

In this first single-cell RNA-seq study of tetramer-sorted T cells from untreated celiac disease patients blood, investigators found that gluten-specific T cells showed distinct transcriptomic profiles consistent with activated effector memory T cells that shared features with Th1 and follicular helper T cells.
[PLOS ONE]
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CD73-Mediated Adenosine Production by CD8 T Cell-Derived Extracellular Vesicles Constitutes an Intrinsic Mechanism of Immune Suppression

The authors showed that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner.
[Nature Communications]
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Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation

The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.
[Immunity]
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Prognostic Implications of Tumor-Infiltrating T Cells in Early-Stage Endometrial Cancer

The proportion of T cells and their subpopulations were associated with clinicopathological features and relapse-free survival outcomes. CD3+ CD4+ infiltrates were more abundant in the patients with higher grade or non-endometrioid histology.
[Modern Pathology]
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Proinflammatory Cytokines Promote TET2-Mediated DNA Demethylation during CD8 T Cell Effector Differentiation

To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, scientists explored the role of interleukin-12 in the imprinting of IFNg expression during CD8 T cell priming.
[Cell Reports]
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PI3Kδ Coordinates Transcriptional, Chromatin, and Metabolic Changes to Promote Effector CD8+ T Cells at the Expense of Central Memory

Using patient samples and a mouse model, scientists demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that were associated with increased Fas-mediated apoptosis.
[Cell Reports]
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Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression

Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.
[Nature Communications]
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The Unique Symptom Burden of Patients Receiving CAR T-Cell Therapy

Patients who received standard CAR T cell therapy experienced numerous symptoms related to disease and CAR T cell therapy, including symptoms related to the T cell infusion.
[Seminars in Oncology]
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Allogeneic Stem Cell Transplantation in Patients with Mantle Cell Lymphoma: Results from the MANTLE-FIRST Study on Behalf of Fondazione Italiana Linfomi

Investigators retrospectively analyzed 55 patients who underwent allogeneic stem cell transplantation for mantle cell lymphoma relapsed or refractory after rituximab and high-dose cytarabine within the MANTLE-FIRST project.
[Leukemia & Lymphoma]
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Features of Repertoire Diversity and Gene Expression in Human Cytotoxic T Cells Following Allogeneic Hematopoietic Cell Transplantation

Scientists showed the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T cells in actual recipients according to the cytomegalovirus reactivation pattern.
[Communications Biology]
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Designing Biomaterials for the Modulation of Allogeneic and Autoimmune Responses to Cellular Implants in Type 1 Diabetes

Designing materials to decrease antigen escape, improve cell viability, and increase material compatibility are all approaches that can decrease the local release of antigen and danger signals into the implant microenvironment.
[Acta Biomaterialia]
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