Metabolic Control of Memory T-Cell Generation and Stemness

The authors describe the different requirements for metabolic programs and metabolism-related signaling pathways in memory T-cell development.
[Cold Spring Harbor Perspectives in Biology]
Raynor, J. L., Chapman, N. M., & Chi, H. (2021). Metabolic Control of Memory T-Cell Generation and Stemness. Cold Spring Harbor Perspectives in Biology, a037770. https://doi.org/10.1101/cshperspect.a037770 Cite
Abstract
Bookmark

No account yet? Register

0
Share

CAR-T Cell Therapy: Current Limitations and Potential Strategies

Scientists discuss recent innovations in CAR-T cell engineering to improve clinical efficacy in both hematological malignancy and solid tumors and strategies to overcome limitations of CAR-T cell therapy in both hematological malignancy and solid tumors.
[Blood Cancer Journal]
Sterner, R. C., & Sterner, R. M. (2021). CAR-T cell therapy: current limitations and potential strategies. Blood Cancer Journal, 11(4), 1–11. https://doi.org/10.1038/s41408-021-00459-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity against CD80/CD86–Positive B Cell Malignancies

CTLA4-chimeric antigen receptor T cells were found to accumulate in tumors and are toxic to myeloid-derived suppressor cells without signs of severe GVHD and CRS in preclinical models.
[Frontiers in Immunology]
Lin, S., Cheng, L., Ye, W., Li, S., Zheng, D., Qin, L., Wu, Q., Long, Y., Lin, S., Wang, S., Huang, G., Li, P., Yao, Y., & Sun, X. (2021). Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.642528 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Designed Proteins Assemble Antibodies into Modular Nanocages

Researchers developed an approach to designing proteins that position antibodies or Fc-fusions on the twofold symmetry axes of regular dihedral and polyhedral architectures.
[Science]
Divine, R., Dang, H. V., Ueda, G., Fallas, J. A., Vulovic, I., Sheffler, W., Saini, S., Zhao, Y. T., Raj, I. X., Morawski, P. A., Jennewein, M. F., Homad, L. J., Wan, Y.-H., Tooley, M. R., Seeger, F., Etemadi, A., Fahning, M. L., Lazarovits, J., Roederer, A., … Baker, D. (2021). Designed proteins assemble antibodies into modular nanocages. Science, 372(6537). https://doi.org/10.1126/science.abd9994 Cite
Abstract
Bookmark

No account yet? Register

0
Share

T Cell Assays Differentiate Clinical and Subclinical SARS-CoV-2 Infections from Cross-Reactive Antiviral Responses

Scientists showed a range of T cell assays that differentially captured immune function to characterise SARS-CoV-2 responses.
[Nature Communications]
Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., Adair, K., Akhter, H. D., Ali, M., Ali, S.-E., Angyal, A., Ansari, M. A., Arancibia-Cárcamo, C. V., Brown, H., Chinnakannan, S., Conlon, C., de Lara, C., de Silva, T., Dold, C., … Dunachie, S. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. Nature Communications, 12(1), 2055. https://doi.org/10.1038/s41467-021-21856-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ADCK1 Activates the β-Catenin/TCF Signaling Pathway to Promote the Growth and Migration of Colon Cancer Cells

Researchers found an increase in ADCK1 (AarF domain-containing kinase 1) expression in clinical specimens of colon cancer and animal models. Downregulation of ADCK1 expression inhibited the colony formation and infiltration of cancer cells, in vivo tumorigenesis, migration, and organoid formation.
[Cell Death & Disease]
Ji, Y., Liu, Y., Sun, C., Yu, L., Wang, Z., Du, X., Yang, W., Zhang, C., Tao, C., Wang, J., Yang, X., Di, S., & Huang, Y. (2021). ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells. Cell Death & Disease, 12(4), 1–12. https://doi.org/10.1038/s41419-021-03624-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Phase II-Like Murine Trial Identifies Synergy between Dexamethasone and Dasatinib in T-Cell Acute Lymphoblastic Leukemia

Scientists performed an shRNA screen in vitro and in vivo in T-cell acute lymphoblastic leukemia cell lines and patient derived xenograft samples to identify vulnerabilities in the pTCR/TCR pathway and identified a critical role for the kinase LCK in cell proliferation.
[Haematologica]
Shi, Y., Beckett, M. C., Blair, H. J., Tirtakusuma, R., Nakjang, S., Enshaei, A., Halsey, C., Vormoor, J., Heidenreich, O., Krippner-Heidenreich, A., & Delft, F. W. van. (2021). Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia. Haematologica, 106(4), 1056–1066. https://doi.org/10.3324/haematol.2019.241026 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Combining Ibrutinib and Checkpoint Blockade Improves CD8+ T-Cell Function and Control of Chronic Lymphocytic Leukemia in Em-TCL1 Mice

By using the Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, scientists observed that ibrutinib effectively controled leukemia development, but also resulted in significantly lower numbers of CD8+ effector T-cells, with lower expression of activation markers, as well as impaired proliferation and effector function.
[Haematologica]
Hanna, B. S., Yazdanparast, H., Demerdash, Y., Roessner, P. M., Schulz, R., Lichter, P., Stilgenbauer, S., & Seiffert, M. (2021). Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice. Haematologica, 106(4), 968–977. https://doi.org/10.3324/haematol.2019.238154 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Diffuse Large B-Cell Lymphoma: New Targets and Novel Therapies

Three CAR-T cell products are currently approved by the FDA, with others in clinical trials. Additional agents in development include bispecific antibodies and antibody drug conjugates.
[Blood Cancer Journal]
Cheson, B. D., Nowakowski, G., & Salles, G. (2021). Diffuse large B-cell lymphoma: new targets and novel therapies. Blood Cancer Journal, 11(4), 1–10. https://doi.org/10.1038/s41408-021-00456-w Cite
Full Article
Bookmark

No account yet? Register

0
Share

Outcome of Haploidentical versus Matched Sibling Donors in Hematopoietic Stem Cell Transplantation for Adult Patients with Acute Lymphoblastic Leukemia: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Investigators retrospectively analyzed adult patients with acute lymphoblastic leukemia who underwent their first allogeneic stem cell transplantation in first or second complete remission between 2012 and 2018, either from a T cell replete Haplo or matched sibling donor donor.
[Journal of Hematology & Oncology]
Nagler, A., Labopin, M., Houhou, M., Aljurf, M., Mousavi, A., Hamladji, R.-M., Al Zahrani, M., Bondarenko, S., Arat, M., Angelucci, E., Koc, Y., Gülbas, Z., Sica, S., Bourhis, J. H., Canaani, J., Brissot, E., Giebel, S., & Mohty, M. (2021). Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Journal of Hematology & Oncology, 14(1), 53. https://doi.org/10.1186/s13045-021-01065-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share