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Immunology of Infectious Disease News

Transient Viral Exposure Drives Functionally-Coordinated Humoral Immune Responses in HIV-1 Post-treatment Controllers

[Nature Communications] Scientists performed comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers.
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Immunology of Infectious Disease News

Safety and Tolerability of AAV8 Delivery of a Broadly Neutralizing Antibody in Adults Living with HIV: A Phase 1, Dose-Escalation Trial

[Nature Medicine] Investigators administered a recombinant bicistronic adeno-associated virus (AAV8) vector coding for both the light and heavy chains of the potent broadly neutralizing HIV-1 antibody VRC07 to eight adults living with HIV.
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Immunology of Infectious Disease News

Elimination of Receptor Binding by Influenza Hemagglutinin Improves Vaccine-Induced Immunity

[NPJ Vaccines] Researchers generated a virus-like particle (VLP) vaccine bearing the hemagglutinin of H1N1 A/California/07/09 that was unable to bind to its α(2,6)-linked sialic acid receptor and compared its immunogenicity and efficacy to a wild-type H1-VLP in mice.
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Immunology of Infectious Disease News

HIV-1 Vpr Drives a Tissue Residency-Like Phenotype during Selective Infection of Resting Memory T Cells

[Cell Reports] Investigators showed that HIV-1 cell-to-cell spread permited efficient, productive infection of resting memory T cells without prior activation.
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Immunology of Infectious Disease News

Safety and Tolerability of AAV8 Delivery of a Broadly Neutralizing Antibody in Adults Living with HIV: A Phase 1, Dose-Escalation Trial

[Nature Medicine] Investigators administered a recombinant bicistronic adeno-associated virus (AAV8) vector coding for both the light and heavy chains of the potent broadly neutralizing HIV-1 antibody VRC07 to eight adults living with HIV.
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Human Immunology News

Single-Cell Characterization of Leukemic and Non-Leukemic Immune Repertoires in CD8+ T Cell Large Granular Lymphocytic Leukemia

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.
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