T cells

[Nature Communications] Scientists performed comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers.

[NPJ Vaccines] Researchers generated a virus-like particle (VLP) vaccine bearing the hemagglutinin of H1N1 A/California/07/09 that was unable to bind to its α(2,6)-linked sialic acid receptor and compared its immunogenicity and efficacy to a wild-type H1-VLP in mice.

[Nature Medicine] Investigators administered a recombinant bicistronic adeno-associated virus (AAV8) vector coding for both the light and heavy chains of the potent broadly neutralizing HIV-1 antibody VRC07 to eight adults living with HIV.

[Cell Reports] Investigators showed that HIV-1 cell-to-cell spread permited efficient, productive infection of resting memory T cells without prior activation.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.

[Nature Communications] Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.