T cells

[Scientific Reports] Murine splenocytes were differentiated into T helper 17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied.

[Scientific Reports] Researchers examined whether haem oxygenase-1 (HO-1) could enhance the immunosuppressive effects of bone marrow MSCs (BMMSCs) on the rejection of transplanted liver allografts in rats.

[Nature Immunology] Researchers combined a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associated specific immune trajectories with upper airway viral containment.

[Nature] Scientists demonstrated that a trispecific antibody to HER2, CD3 and CD28 stimulated regression of breast cancers in a humanized mouse model through a mechanism involving CD4-dependent inhibition of tumor cell cycle progression.

[Mucosal Immunology] Investigators hypothesize that memory responses to antigens from the microbiota must be ‘licensed’ by inflammatory signals activated by invasion of the host by microorganisms.

[PLoS Biology] Scientists reported that mice with Treg cell–specific ablation of miR-142 developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T cell tolerance.