Impaired T Cell Responses in Domestic Pigs and Wild Boar upon Infection with a Highly Virulent African Swine Fever Virus Strain

Researchers investigated T cell responses of domestic pigs and wild boar upon infection with the highly virulent ASF virus strain “Armenia08”.
[Transboundary and Emerging Diseases]
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Oligodendrocytes That Survive Acute Coronavirus Infection Induce Prolonged Inflammatory Responses in the CNS

Using a lineage-tracking system, investigators showed that some cells, primarily oligodendrocytes and oligodendrocyte precursor cells, survived the acute mouse hepatitis infection, were associated with regions of demyelination, and persisted in the central nervous system for at least 150 days.
[Proceedings of the National Academy of Sciences of the United States of America]
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Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

Investigators give an overview of T cell receptors identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field.
[Cells]
Healy, K., Pasetto, A., Sobkowiak, M. J., Soon, C. F., Cornberg, M., Aleman, S., & Chen, M. S. (2020). Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies. Cells, 9(6), 1471. https://doi.org/10.3390/cells9061471 Cite
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Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination with Carboplatin in Patients with Advanced Solid Tumors

This Phase I trial assessed the ATR inhibitor M6620 as monotherapy and combined with carboplatin. Primary objectives were safety, tolerability, and maximum tolerated dose.
[Journal of Clinical Oncology]
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Circulating Immune Cell Phenotype Dynamics Reflect the Strength of Tumor–Immune Cell Interactions in Patients during Immunotherapy

Using an ecological population model, fitted to clinical tumor burden and immune cell abundance data from each patient, we find evidence of a strong tumor-circulating immune cell interaction in responder patients but not in those patients that progress on treatment.
[Proceedings of the National Academy of Sciences of the United States of America]
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Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells

Investigators report the ability of a scalable hollow fiber bioreactor to effectively maintain ideal mesenchymal stem cell function as a single population while also being able to impart an immunoregulatory effect when cultured in tandem with an inflamed lymphocyte population.
[Scientific Reports]
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Clinical Relevance of B7H3 Expression in Retinoblastoma

Scientists validated the previous finding by Western blotting and immunohistochemistry on primary retinoblastoma (RB) tumor samples. The results suggested significantly increased expression of B7H3 in RB tumor samples compared to retina by western blotting.
[Scientific Reports]
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Development of CAR-T Cell Therapies for Multiple Myeloma

Main challenges to CAR-T cell therapy will be highlighted as well as strategies to structurally improve the CAR-T cell product, and thereby its efficacy and safety.
[Leukemia]
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Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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Human MAIT Cell Cytolytic Effector Proteins Synergize to Overcome Carbapenem Resistance in Escherichia coli

Scientists showed that mucosa-associated invariant T (MAIT) cells mediate MR1-restricted antimicrobial activity against Escherichia coli clinical strains in a manner dependent on the activity of cytolytic proteins but independent of production of pro-inflammatory cytokines or induction of apoptosis in infected cells.
[PLoS Biology]
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