T cells

[Cell Reports Medicine] The authors analyzed whole-exome and bulk RNA sequencing of tumors from new and published cohorts of 189 and 178 patients with melanoma receiving checkpoint blockade, respectively.

[Hepatology] Scientists analyzed the immune landscapes of hypoxia-low and -high tumor regions using cytometry by time-of-flight, immunohistochemistry and transcriptomic analyses.

[Frontiers in Immunology] Using a human in vitro tri-culture system of macrophages with activated autologous T cells and BRAFV600E mutant melanoma cells, scientists showed that activated T cells and the synthetic triterpenoid the methyl CDDO-Me attenuated immune suppression.

[Journal of Immunology] The authors found that human mucosa-associated invariant T (MAIT)cells are hypersensitive to leukocidin ED-mediated lysis and lost on exposure to the toxin, leaving a T cell population devoid of MAIT cells.

[Cell Reports] Using Powassan virus lethal and sub-lethal challenge models, the authors showed that robust B and T cell responses were necessary for immune protection.

[iScience] Investigators evaluated the immune properties of the HLA-A2 restricted CD8+ T cell epitopes containing mutations from B.1.1.7.