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T cells

Identification of Genomic Signatures in Bone Marrow Associated with Clinical Response of CD19 CAR T Cell Therapy

[Scientific Reports] In patients achieving a complete response (CR) transcriptomic profiles of bone marrow prior to lymphodepletion showed genes mainly involved in T cell activation.

The Development of Chiral Nanoparticles to Target NK Cells and CD8+ T Cells for Cancer Immunotherapy

[Advanced Materials] Researchers investigated the immunological effect of chiral nanomaterials as therapeutic and preventive options against tumors.

IL-36 Cytokines Imprint a Colitogenic Phenotype on CD4+ T Helper Cells

[Mucosal Immunology] Scientists reported specifically elevated expression of IL-36α, and not IL-36β or IL-36γ in the serum of newly diagnosed, treatment naïve, pediatric inflammatory bowel diseases patients and identify T cells as primary cellular mediators of IL-36 responses in the inflamed gut.

Human Umbilical Cord Mesenchymal Stem Cells Alleviate the Imbalance of CD4+ T Cells via Protein Tyrosine Phosphatase Non-receptor Type 2/Signal Transducer and Activator of...

[Endocrine Journal] Human umbilical cord mesenchymal stem cells treatment significantly alleviated inflammation, reduced serum thyroid antibody levels, and decreased the ratios of IL-17α+/CD25+FOXP3+ cells and serum IFN-γ/IL-4 in experimental autoimmune thyroiditis rats.

T Cell Dysfunction in the Glioblastoma Microenvironment Is Mediated by Myeloid Cells Releasing Interleukin-10

[Nature Communications] Researchers showed that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drove T cell exhaustion and thus contributed to the immunosuppressive tumor microenvironment.

Adaptive NK Cells Undergo a Dynamic Modulation in Response to Human Cytomegalovirus and Recruit T Cells in In Vitro Migration Assays

[Bone Marrow Transplantation] Investigators studied the relationship between human cytomegalovirus reactivation and adaptive NK cells in 70 patients monitored weekly until 100 days after hematopoietic stem cell transplantation

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