T cells

[Cell Host & Microbe] Investigators reported the development of two pools of experimentally-defined SARS-CoV-2 T cell epitopes, that in combination with spike, were used to discriminate four groups of subjects with different SARS-CoV-2 infection and COVID-19 vaccine status.

[Immunological Reviews] Scientists review our current understanding of how each of the three signals plays a role in three different autoimmune diseases and highlight the genetic polymorphisms that predispose individuals to autoimmunity.

[Leukemia] In co-cultures from 28 different chronic lymphocytic leukemia patients, the authors detected an expansion of T-follicular helper cells based on PD-1, BCL6, and ICOS expression, with increased IL-21 and downmodulated CD40L surface expression.

[Science] Scientists determined that complement component 3 bound to peptide-loaded major histocompatibility complex class II molecules exposed on the surface of mouse and human conventional dendritic cells, forming a covalent bond with the carbohydrate moiety of the MHC II α chain.

[Oncogene] Scientists created type I interferon (IFN)α-overexpressing MSCs. Upon direct injection into tumors, they found that these cells were powerful in eliminating several types of tumors.

[Clinical Cancer Research] Digital image analysis of whole section slides was used to assess abundance and spatial distribution of T cells and tertiary lymphoid structures in the tumor immune microenvironment of 117 tumor samples.