T cells

[Cell Reports] Scientists evaluated the global mapping of VEGF-mediated dynamic transcriptional events, focusing on major histone-code profiles using chromatin immunoprecipitation sequencing.

[Nature] The authors presented the clinical experience from the first four patients with H3K27M-mutant diffuse intrinsic pontine glioma/diffuse midline glioma treated with GD2-CAR T cells at dose level 1.

[PLoS Pathogens] Researchers investigated whether infusion of T cells expressing an simian immunodeficiency virus-specific chimeric antigen receptor and the follicular homing receptor, CXCR5, could successfully kill viral-RNA+ cells in targeted lymphoid follicles in SIV-infected rhesus macaques.

[Journal of Virology] Scientists reported the pathogenic and immunological consequences of SARS-CoV-2 and influenza A virus H1N1 coinfection in the K18-hACE2 transgenic mouse model.

[Ebiomedicine] Scientists review recent evidence on the role of immune checkpoints in persistent HIV infection and discuss the potential for employing immune checkpoint blockade as a therapeutic approach to target HIV persistence on antiretroviral therapy.

[Journal of Clinical Investigation] The authors observed that the HIV-1 proviral landscape was different and changed with time on antiretroviral therapy across naïve and memory CD4+ T cell subsets isolated from 24 participants.