T cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated inflammatory signaling pathways in neuroblastoma, a classically “cold” pediatric cancer. By testing the functional response of a panel of 20 diverse neuroblastoma cell lines to three different inflammatory stimuli, they found that all cell lines have intact interferon signaling.

[EMBO Journal] Single-cell transcriptomics of LAT-deficient double-negative third stage γδint cells demonstrated no sign of commitment to the γδ T-cell lineage, apart from γδ T cell receptor expression.

[Lancet Haematology] Scientists reported the results of a prospective, single-arm, Phase II clinical trial done at the University Medical Center Utrecht and the Princess Máxima Center for Pediatric Oncology to investigate individualized dosing of anti-thymocyte globulin for unrelated allogeneic HSC transplantation in pediatric patients.

[Cell Reports] Using single-cell sequencing, scientists showed that tumor-induced lymphocytes include skewed T cell clonotypes, which were characterized by exhaustion or nonexhaustion signatures.

[NeoImmuneTech, Inc. (Businesswire, Inc.)] NeoImmuneTech, Inc. announced that the first patient has been dosed in the Phase IIa portion of a study evaluating NT-I7, a novel long-acting human interleukin-7, in combination with the PD-L1 targeting drug atezolizumab, in patients with advanced high-risk skin cancers including melanoma, merkel cell carcinoma, and cutaneous squamous cell carcinoma.

[American Journal of Hematology] A single-arm exploratory clinical trial is the first to evaluate the safety and efficacy of sequential anti-CD19 and anti-BCMA CAR-T cell infusion, followed by lenalidomide maintenance after autologous stem-cell transplantation in ten high-risk newly diagnosed multiple myeloma patients.