T cells

[Hepatology] Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.

[Molecular Biology Reports] IL-21 has profound effects on tumor growth and immunosurveillance of colitis-associated tumourigenesis, thereby emphasising its involvement in the pathogenesis of colorectal cancer.

[Febs Letters] Investigators address potential future targets to overcome the flaws of CAR-T cell technology in the treatment of cancer, emphasizing glycan antigens, the aberrant forms of which attain high tumour-specific expression, as alternative targets for CAR-T cells.

[Cancer Immunology Research] Investigators combined intratumoral STimulator of INterferon Genes (STING) agonist therapy with systemically injected extended half-life IL2 and anti–PD-1 checkpoint blockade to drive innate and adaptive antitumor immunity in models of triple-negative breast cancer.

[Cellular & Molecular Immunology] Scientists summarize the recent advances in expansion strategies with or without genetic manipulation of NK cells derived from various cellular sources.

[International Journal of Stem Cells] Researchers reported the effects of diesel exhaust particles exposure on the properties of human Wharton’s jelly-derived mesenchymal stem cells, including stemness, regeneration, and immunomodulation.