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T cells

Mesenchymal Stromal Cells: A Possible Reservoir for HIV-1?

[Stem Cell Reviews and Reports] Mesenchymal stem cells appear to have the potential to contribute to the HIV-1 reservoir. Further studies are needed using techniques such as those used to prove that cluster of differentiation (CD)4+ T cells constitute an HIV-1 reservoir before a reservoir function can definitively be ascribed to MSCs.

B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer

[Frontiers in Immunology] Researchers used a novel interleukin 35 reporter model to understand which signaling pathways are important for immunosuppressive properties in B cells.

Generation of a B2M Homozygous Knockout Human Somatic Cell Nuclear Transfer-Derived Embryonic Stem Cell Line Using the CRISPR/Cas9 System

[Stem Cell Research] The authors generated a Beta2-microglobulin (B2M) homozygous knockout somatic cell nuclear transfer-induced ESC line using CRISPR/Cas9-mediated gene targeting.

Anti-CAIX BBζ CAR4/8 T Cells Exhibit Superior Efficacy in a Clear Cell Renal Cell Carcinoma (ccRCC) Mouse Model

[Molecular Therapy Oncolytics] The authors compared second-generation with third-generation carbonic anhydrase IX targeted CAR constructs and investigated the anti-tumor effect of CAR-T cells with different CD4/CD8 proportions in vitro and in vivo.

GPC2-CAR T Cells Tuned for Low Antigen Density Mediate Potent Activity against Neuroblastoma without Toxicity

[Cancer Cell] Scientists developed T cells expressing CARs targeting glypican-2 (GPC2), a fetal antigen expressed on neuroblastoma and several other solid tumors.

Engineering CAR-T Cells to Activate Small-Molecule Drugs In Situ

[Nature Chemical Biology] To overcome these problems, scientists developed a novel class of CAR-T cells engineered to express an enzyme that activated a systemically administered small-molecule prodrug in situ at a tumor site.

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