T cells

[Journal of Experimental & Clinical Cancer Research] The authors assessed the efficacy and safety of B cell maturation antigen (BCMA) and CD38 bispecific CAR-T cells in refractory multiple myeloma patients.

[Cancer Letters] Investigators showed that suboptimal T cell receptor stimulation of CD8+ T cells upregulated FOXP3 in vitro.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that teprotumumab, an anti-insulin-like growth factor I receptor inhibitor, attenuated constitutive expression and induction by the thyroid-stimulating hormone of MHC II and these B7 members in CD34+ fibrocytes.

[Clinical Cancer Research] Investigators examined the role of the CD137+ T cells in the improvement of patients' selection for immunotherapy treatment.

[International Journal of Biological Sciences] Efforts have been made to generate immune-escaping human embryonic stem cells where T cell immunity was evaded by defecting β-2-microglobulin, a common unit for human leukocyte antigen class I, and NK cells were inhibited via ectopic expression of HLA-E or -G.

[PLoS One] The authors demonstrated that papaya mosaic (PapMV) virus nanoparticles did not require the transporter associated with antigen presentation, but rather depended on lysosome acidification and cathepsin S protease activity for presentation of the T cell epitope.