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T cells

Anatomically Distinct Fibroblast Subsets Determine Skin Autoimmune Patterns

[Nature] The authors identified subsets of dermal fibroblasts that were responsible for driving patterned autoimmune activity, by using a robust mouse model of vitiligo that was based on the activation of endogenous auto-reactive CD8+ T cells that targeted epidermal melanocytes.

Cell Membrane Breakage and Triggering T Cell Infiltration Are Involved in Human Telomerase Reverse Transcriptase (hTERT) Promoter-Driven Novel Peptide Kk-64 for Liver Cancer Gene...

[Bioengineered] Researchers designed a new peptide KK-64, and it showed strong cytotoxicity against liver cancer cells. To obtain the tumor targeting property, a plasmid that contains KK-64 DNA fragment and driven by hTERT promoter was constructed.

Soluble CD137 Is a Novel Serum Marker of Liver Cirrhosis in Patients with Hepatitis C and Alcohol-Associated Disease Etiology

[European Journal of Immunology] Serum soluble CD137 (sCD137) is associated with inflammatory states, and positively correlated with serum tumor necrosis factor in cirrhotic hepatitis C virus (HCV) patients following virus eradication. Researchers argued against a role of sCD137 in HCV infection and suggested a function of sCD137 in liver cirrhosis.

LncRNA LINC00184 Promotes Docetaxel Resistance and Immune Escape via miR-105-5p/Pd-L1 Axis in Prostate Cancer

[Immunobiology] The authors explored the function and mechanism of LINC00184 in docetaxel resistance of prostate cancer and found that LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulting in upregulation of the expression of PD-L1.

Transient Receptor Potential Cation Channel Subfamily V (TRPV) and Its Importance in Asthma.

[European Journal of Pharmacology] Transient receptor potential vanilloid 2 (TRPV2) may represent a novel biomarker for asthma in children; meanwhile, TRPV1 and TRPV4 seem to be essential contributors to the development and exacerbations of asthma.

Functional Impairment of CD19+CD24hiCD38hi B Cells in Neuromyelitis Optica Spectrum Disorder Is Restored by B Cell Depletion Therapy

[Science Translational Medicine] Investigators evaluated the B cell subsets, Breg cell function, and the effect of B cell depletion therapy on these cells in patients with neuromyelitis optica spectrum disorder.

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