T cells

[Proceedings of the National Academy of Sciences of the United States of America] Using exome sequencing, RNA-sequencing, and functional immunologic studies, scientists characterized 28 normal karyotype (NK)-AML patients with over 5 year first remissions after chemotherapy and compared them to a well-matched group of 31 NK-AML patients who relapsed within two years.

[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists used desmoglein 3, a pemphigus antigen expressed in keratinocytes, to analyze peripheral tolerance under physiological antigen-expression conditions.

[Cancer Immunology Research] An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 as a suppressor of PD-L1 expression.

[Cell Reports] To gain a deeper understanding of the molecular characteristics associated with CAR T cell differentiation, researchers performed longitudinal genome-wide DNA methylation profiling of CD8+ CD19-CAR T cells post-infusion in acute lymphoblastic leukemia patients.

[PLoS One] Scientists revealed a lymphoid TBX-code and used it to identify an aberrant network around deregulated T-box gene TBX3 in Hodgkin lymphoma which promoted hallmark aberrations of this disease.