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T cells

Acute Myeloid Leukemia Cell Membrane-Coated Nanoparticles for Cancer Vaccination Immunotherapy

[Leukemia] Researchers reported the development of an acute myeloid leukemia cell membrane-coated nanoparticle vaccine platform, in which immune-stimulatory adjuvant-loaded nanoparticles were coated with leukemic cell membrane material.

Anlotinib Induces a T Cell-Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD1 Checkpoint Blockade in Neuroblastoma

[Clinical Cancer Research] Researchers proved that anlotinib facilitated tumor vessel normalization at least partially through CD4+ T cells, reprogrammed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression.

Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance

[Gynecological Oncology] Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence

Protective Activity of mRNA Vaccines against Ancestral and Variant SARS-CoV-2 Strains

[Science Translational Medicine] The authors assessed the immunogenicity and protective activity of historical or modified Moderna mRNA vaccines in 129S2 and K18-hACE2 mice.

A Single Dose, BCG-Adjuvanted COVID-19 Vaccine Provides Sterilising Immunity against SARS-CoV-2 Infection

[NPJ Vaccines] Scientists exploited the immunostimulatory properties of bacille Calmette-Guérin, the existing tuberculosis vaccine, to deliver a vaccination regimen with potent SARS-CoV-2-specific protective immunity.

Mucosal Tissue Regulatory T Cells Are Integral in Balancing Immunity and Tolerance at Portals of Antigen Entry

[Mucosal Immunology] Scientists summarize current knowledge regarding mucosal Tregs in both health and disease.

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