Tag results:
T cells
Hematopoiesis News
Acute Myeloid Leukemia Cell Membrane-Coated Nanoparticles for Cancer Vaccination Immunotherapy
[Leukemia] Researchers reported the development of an acute myeloid leukemia cell membrane-coated nanoparticle vaccine platform, in which immune-stimulatory adjuvant-loaded nanoparticles were coated with leukemic cell membrane material.
Extracellular Matrix News
Anlotinib Induces a T Cell-Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD1 Checkpoint Blockade in Neuroblastoma
[Clinical Cancer Research] Researchers proved that anlotinib facilitated tumor vessel normalization at least partially through CD4+ T cells, reprogrammed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression.
Extracellular Matrix News
Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance
[Gynecological Oncology] Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence
Immunology of Infectious Disease News
Protective Activity of mRNA Vaccines against Ancestral and Variant SARS-CoV-2 Strains
[Science Translational Medicine] The authors assessed the immunogenicity and protective activity of historical or modified Moderna mRNA vaccines in 129S2 and K18-hACE2 mice.
Immunology of Infectious Disease News
A Single Dose, BCG-Adjuvanted COVID-19 Vaccine Provides Sterilising Immunity against SARS-CoV-2 Infection
[NPJ Vaccines] Scientists exploited the immunostimulatory properties of bacille Calmette-Guérin, the existing tuberculosis vaccine, to deliver a vaccination regimen with potent SARS-CoV-2-specific protective immunity.
Human Immunology News
Mucosal Tissue Regulatory T Cells Are Integral in Balancing Immunity and Tolerance at Portals of Antigen Entry
[Mucosal Immunology] Scientists summarize current knowledge regarding mucosal Tregs in both health and disease.