Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells

Investigators report the ability of a scalable hollow fiber bioreactor to effectively maintain ideal mesenchymal stem cell function as a single population while also being able to impart an immunoregulatory effect when cultured in tandem with an inflamed lymphocyte population.
[Scientific Reports]
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Clinical Relevance of B7H3 Expression in Retinoblastoma

Scientists validated the previous finding by Western blotting and immunohistochemistry on primary retinoblastoma (RB) tumor samples. The results suggested significantly increased expression of B7H3 in RB tumor samples compared to retina by western blotting.
[Scientific Reports]
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Development of CAR-T Cell Therapies for Multiple Myeloma

Main challenges to CAR-T cell therapy will be highlighted as well as strategies to structurally improve the CAR-T cell product, and thereby its efficacy and safety.
[Leukemia]
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Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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Human MAIT Cell Cytolytic Effector Proteins Synergize to Overcome Carbapenem Resistance in Escherichia coli

Scientists showed that mucosa-associated invariant T (MAIT) cells mediate MR1-restricted antimicrobial activity against Escherichia coli clinical strains in a manner dependent on the activity of cytolytic proteins but independent of production of pro-inflammatory cytokines or induction of apoptosis in infected cells.
[PLoS Biology]
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T-Cell Responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients

Investigators evaluated the CD4+ and CD8+ responses to influenza A and B infection in a cohort of solid organ transplant patients.
[Scientific Reports]
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Peripherally Induced Brain Tissue–Resident Memory CD8+ T Cells Mediate Protection against CNS Infection

Researchers showed that peripheral infections generated antigen-specific CD8+ memory T cells in the brain that adopted a unique tissue resident memory signature.
[Nature Immunology]
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Generation of Knockout Rabbits with X-Linked Severe Combined Immunodeficiency (X-SCID) Using CRISPR/Cas9

X-SCID rabbits presented immunodeficient phenotypes including the loss of T and B cells and hypoplasia of the thymus.
[Scientific Reports]
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PD-L1 Expression by Dendritic Cells Is a Key Regulator of T-Cell Immunity in Cancer

Investigators demonstrated that dendritic cells represented a critical source of PD-L1, despite being vastly outnumbered by PD-L1+ macrophages.
[Nature Cancer]
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Tet2 and Tet3 in B Cells Are Required to Repress CD86 and Prevent Autoimmunity

The authors report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
[Nature Immunology]
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