How to Turn Up the Heat on the Cold Immune Microenvironment of Metastatic Prostate Cancer

The authors discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.
[Prostate Cancer and Prostatic Diseases]
Stultz, J., & Fong, L. (2021). How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer. Prostate Cancer and Prostatic Diseases, 1–21. https://doi.org/10.1038/s41391-021-00340-5 Cite
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The Importance of Cellular and Exosomal miRNAs in Mesenchymal Stem Cell Osteoblastic Differentiation

The importance of MSC miRNAs in modulation of osteoblastic differentiation was examined by global reduction of miRNA biosynthesis in Dicer knock down hMSCs.
[Scientific Reports]
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Comprehensive Upstream and Downstream Regulatory Analyses Identify miR-675-3p as a Potential Prognostic Biomarker in Melanoma

Researchers assessed miR-675-3p-related regulatory mechanisms in melanoma and the clinical relevance of such regulatory activities.
[Human Cell]
Zhao, C.-C., Guo, H., Wang, Y., & Li, J.-H. (2021). Comprehensive upstream and downstream regulatory analyses identify miR-675-3p as a potential prognostic biomarker in melanoma. Human Cell. https://doi.org/10.1007/s13577-020-00473-0 Cite
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A Biomimetic Engineered Bone Platform for Advanced Testing of Prosthetic Implants

To build a testing platform for advanced characterization of bone implants, investigators anchored model prosthetic titanium and stainless steel implants into decellularized bone scaffolds, seeded the implant-scaffold constructs with induced MSCs, and cultured the samples in an osteogenic environment in the presence of osteogenic inducing factors to grow bone tissue in vitro.
[Scientific Reports]
Sladkova-Faure, M., Pujari-Palmer, M., Öhman-Mägi, C., López, A., Wang, H., Engqvist, H., & de Peppo, G. M. (2020). A biomimetic engineered bone platform for advanced testing of prosthetic implants. Scientific Reports, 10(1), 22154. https://doi.org/10.1038/s41598-020-78416-w Cite
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Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Rejuvenates Aged Muscle Mass and Strength

The authors identified elevated 15-PGDH, the prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The resulting reduction in PGE2 signaling was a major contributor to muscle atrophy in aged mice and resulted from 15-PGDH-expressing myofibers and interstitial cells within muscle.
[Science]
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Systems Biology Analysis of Osteogenic Differentiation Behavior by Canine Mesenchymal Stem Cells Derived from Bone Marrow and Dental Pulp

The authors illustrated that canine dental pulp stem cells contained superior osteogenicity comparing with canine bone marrow-derived MSCs regarding alkaline phosphatase activity, matrix mineralization, and osteogenic marker expression.
[Scientific Reports]
Nantavisai, S., Pisitkun, T., Osathanon, T., Pavasant, P., Kalpravidh, C., Dhitavat, S., Makjaroen, J., & Sawangmake, C. (2020). Systems biology analysis of osteogenic differentiation behavior by canine mesenchymal stem cells derived from bone marrow and dental pulp. Scientific Reports, 10(1), 20703. https://doi.org/10.1038/s41598-020-77656-0 Cite
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Duchenne Muscular Dystrophy (DMD) Cardiomyocyte-Secreted Exosomes Promote the Pathogenesis of DMD-Associated Cardiomyopathy

Investigators determine the phenotypic responses of DMD cardiomyocytes (DMD-iCMs) after long-term exposure to DMD cardiac exosomes. DMD-iCMs were vulnerable to stress, evidenced by production of reactive oxygen species, the mitochondrial membrane potential and cell death levels.
[Disease Models & Mechanisms]
Gartz, M., Lin, C.-W., Sussman, M. A., Lawlor, M. W., & Strande, J. L. (2020). Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Disease Models & Mechanisms, 13(11). https://doi.org/10.1242/dmm.045559 Cite
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DNA Methylation across the Genome in Aged Human Skeletal Muscle Tissue and Muscle-Derived Cells: The Role of HOX Genes and Physical Activity

Using 850K DNA methylation arrays researchers compared the methylomes of young and aged human skeletal muscle and that of young/aged heterogenous muscle-derived human primary cells over several time points of differentiation.
[Scientific Reports]
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Bristol Myers Squibb Enters Agreement to Acquire Forbius, Adding Lead TGF-Beta Asset to Portfolio

Bristol Myers Squibb and Forbius have announced that they have entered into a definitive agreement under which Bristol Myers Squibb will acquire Forbius. Forbius has developed a portfolio of highly selective and potent inhibitors of TGF-beta 1 & 3, which are key mediators of immunosuppression and fibrosis.
[Bristol Myers Squibb]
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Additive Clinical Impact of Epidermal Growth Factor Receptor and Podocalyxin-Like Protein Expression in Pancreatic and Periampullary Adenocarcinomas

The effect of transforming growth factor β-induced expression and siRNA-mediated knockdown of podocalyxin-like protein and epidermal growth factor receptor, were investigated in pancreatic cancer cells in vitro.
[Scientific Reports]

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TGF-β Induced EMT and Stemness Characteristics are Associated with Epigenetic Regulation in Lung Cancer

Scientists determined whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer.
[Scientific Reports]
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