The authors illustrated that canine dental pulp stem cells contained superior osteogenicity comparing with canine bone marrow-derived MSCs regarding alkaline phosphatase activity, matrix mineralization, and osteogenic marker expression.
Investigators determine the phenotypic responses of DMD cardiomyocytes (DMD-iCMs) after long-term exposure to DMD cardiac exosomes. DMD-iCMs were vulnerable to stress, evidenced by production of reactive oxygen species, the mitochondrial membrane potential and cell death levels.
Gartz, M., Lin, C.-W., Sussman, M. A., Lawlor, M. W., & Strande, J. L. (2020). Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Disease Models & Mechanisms, 13(11). https://doi.org/10.1242/dmm.045559Cite
Using 850K DNA methylation arrays researchers compared the methylomes of young and aged human skeletal muscle and that of young/aged heterogenous muscle-derived human primary cells over several time points of differentiation.
Bristol Myers Squibb and Forbius have announced that they have entered into a definitive agreement under which Bristol Myers Squibb will acquire Forbius. Forbius has developed a portfolio of highly selective and potent inhibitors of TGF-beta 1 & 3, which are key mediators of immunosuppression and fibrosis.
The effect of transforming growth factor β-induced expression and siRNA-mediated knockdown of podocalyxin-like protein and epidermal growth factor receptor, were investigated in pancreatic cancer cells in vitro.
Heby, M., Karnevi, E., Elebro, J., Nodin, B., Eberhard, J., Saukkonen, K., Hagström, J., Mustonen, H., Seppänen, H., Haglund, C., Jirström, K., & Larsson, A. H. (2020). Additive clinical impact of epidermal growth factor receptor and podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomas. Scientific Reports, 10(1), 1–10. https://doi.org/10.1038/s41598-020-67187-zCite