TLR4

[inflammopharmacology] Researchers investigated the effect of curcumin on vascular smooth muscle cells inflammation induced by lipopolysaccharide and its mechanism.

[FASEB Journal] Researchers studied the crosstalk between hyaluronan in the tumor microenvironment and macrophages dependent lymphangiogenesis, providing new insight into tumor microenvironment remodeling and macrophages in breast cancer lymphangiogenesis.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediate the arrest of neutrophils, a step upstream of their extravasation.

[Cell Reports] Scientists reported that high-level mitochondrial respiration and constitutive low-level glycolysis supported liver sinusoidal endothelial cells scavenger and sentinel functions

[Stem Cell Reports] The authors findings supported a direct role for SARS-CoV-2 in mediating endothelial inflammation in an ACE2-dependent or -independent manner.

[Scientific Reports] The effects of the ferroptosis inhibitor ferrostatin-1 on endothelial cell ferroptosis and pulmonary vascular remodelling in monocrotaline-induced rats were studied in vitro and in vivo.