TRPV4

[Nature Communications] Researchers used a human lung alveolus chip that experienced cyclic breathing-like deformations to investigate whether physical forces influenced innate immune responses to viral infection.

[Journal of Hematology & Oncology] Investigators summarize recent work on the regulation of ECM stiffness in cancer and the effects of ECM stiffness on tumor progression, cancer immunity, and drug resistance.

[Developmental Cell] Scientists studied the formation of the zebrafish atrioventricular canal where cardiac valves developed and identified how mechanical forces and ECM influenced tissue remodeling in developing organs.

[Biophysical Journal] Transient receptor potential vanilloid 4 (TRPV4) enabled endothelial cells, smooth muscle cells, and perivascular neurons, to integrate hemodynamic forces to regulate systemic blood pressure.

[Nanotoxicology] In this in vitro study scientists assessed the cytotoxic effects of nickel oxide nanoparticles (NiONPs) on human pulmonary artery endothelial cells.

[European Journal of Pharmacology] Transient receptor potential vanilloid 2 (TRPV2) may represent a novel biomarker for asthma in children; meanwhile, TRPV1 and TRPV4 seem to be essential contributors to the development and exacerbations of asthma.