Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
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Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review

The authors systematically review literature pertaining to hematopoietic stem cell (HSC) based tissue engineering strategies in animal models of chondral repair such that trends may be identified and the utility of HSCs in chondral repair can be elucidated
[Tissue Engineering]
Kabir, W., Di Bella, C., Gould, D., Jo, I., & Choong, P. (2020). Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.TEB.2020.0155 Cite
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Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study

67 patients were treated with Wharton’s jelly mesenchymal stem cells. The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 amyotrophic lateral sclerosis clinical studies
[Stem Cell Reviews and Reports]
Barczewska, M., Maksymowicz, S., Zdolińska-Malinowska, I., Siwek, T., & Grudniak, M. (2020). Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10016-7 Cite
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Comparison of Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Isolated from Cryopreserved Material and Extracted by Explantation and Digestion Methods Utilizing a Split Manufacturing Model

Umbilical cord (UC)-derived MSCs were isolated from 10 UC tissue samples by both explantation and enzymatic digestion methods to allow for comparison of cells from the same donor.
[Cytotherapy]
Skiles, M. L., Marzan, A. J., Brown, K. S., & Shamonki, J. M. (2020). Comparison of umbilical cord tissue-derived mesenchymal stromal cells isolated from cryopreserved material and extracted by explantation and digestion methods utilizing a split manufacturing model. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.06.002 Cite
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Neonatal Genetics of Gene Expression Reveal Potential Origins of Autoimmune and Allergic Disease Risk

Investigators mapped expression quantitative trait loci in resting myeloid cells and CD4+ T cells from cord blood samples, as well as in response to lipopolysaccharide or phytohemagglutinin stimulation, respectively.
[Nature Communications]
Huang, Q. Q., Tang, H. H. F., Teo, S. M., Mok, D., Ritchie, S. C., Nath, A. P., Brozynska, M., Salim, A., Bakshi, A., Holt, B. J., Khor, C. C., Sly, P. D., Holt, P. G., Holt, K. E., & Inouye, M. (2020). Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk. Nature Communications, 11(1), 3761. https://doi.org/10.1038/s41467-020-17477-x Cite
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Combined Use of Recombinant Human Bone Morphogenetic Protein-7 and Osteogenic Media May Have No Ideal Synergistic Effect on Bone Regeneration of Human Umbilical Cord Mesenchymal Stem Cells Seeded on Nano-Hydroxyapatite/Collagen/Poly (L-Lactide)

Scientists investigated the effect of recombinant human bone morphogenetic protein-7 and/or osteogenic media on bone regeneration of human umbilical cord-MSCs seeded on nano-hydroxyapatite/collagen/poly in a rabbit model.
[Stem Cells and Development]
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DTI Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients during Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure

A cohort of eight pediatric cereberal palsy (CP) patients with intact corticospinal tracts from a randomized, placebo‐controlled trial of autologous umbilical cord blood stem‐cell therapy in CP children was included in this study.
[Journal of Magnetic Resonance Imaging]
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Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells Maintains and Partially Improves Visual Function in Patients with Advanced Retinitis Pigmentosa

Investigators conducted a Phase I/II clinical trial aiming to evaluate the safety and efficacy of intravenous administration of umbilical cord MSCs in advanced retinitis pigmentosa patients.
[Stem Cells and Development]
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SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Investigators demonstrated for the first time that ACE2 and the entry-facilitating transmembrane protease TMPRSS2 were expressed on very small CD133+CD34+LinCD45 cells in human umbilical cord blood, which could be specified into functional hematopoietic stem cells and endothelial progenitor cells.
[Stem Cell Reviews and Reports]
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GMP-Grade CD34+ Selection from HLA-Homozygous Licensed Cord Blood Units and Short-Term Expansion under European ATMP Regulations

Among 20 639 licensed Düsseldorf cord blood units, 139 potential HLA‐h donors were identified with the most frequent 10 German haplotypes.
[Vox Sanguinis]
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Regeneration of the Rotator Cuff Tendon-to-Bone Interface Using Umbilical Cord-Derived Mesenchymal Stem Cells and Gradient Extracellular Matrix Scaffolds from Adipose Tissue in a Rat Model

Researchers investigated the efficacy of a biomimetic hydroxyapatite-gradient scaffold isolated from adipose tissue with umbilical cord derived MSCs on the regeneration of the structure of the tendone-to-bone interface by analyzing the histological and biomechanical changes in a rat repair model.
[Acta Biomaterialia]
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hUC-MSCs Ameliorated CUMS-Induced Depression by Modulating Complement C3 Signaling-Mediated Microglial Polarization during Astrocyte-Microglia Crosstalk

Human umbilical cord (hUC)-MSCs were administered into chronic unpredictable mild stress model mice through the tail vein once a week for four weeks. After the administration of hUC-MSCs, the depression-like and anxiety-like phenotypes, neuronal histopathology, synaptic-related protein expression and inflammatory index of the mice were assessed.
[Brain Research Bulletin]
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