One Repeated Transplantation of Allogeneic Umbilical Cord Mesenchymal Stromal Cells in Type 1 Diabetes: An Open Parallel Controlled Clinical Study

Scientists examined the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with type 1 diabetes.
[Stem Cell Research & Therapy]
Lu, J., Shen, S., Ling, Q., Wang, B., Li, L., Zhang, W., Qu, D., Bi, Y., & Zhu, D. (2021). One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study. Stem Cell Research & Therapy, 12(1), 340. https://doi.org/10.1186/s13287-021-02417-3 Cite
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Human Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells as Adjuvant Therapy for Myocardial Infarction: A Review of Current Evidence Focusing on Pre-clinical Large Animal Models and Early Human Trials

The available evidence concerning umbilical cord-derived MSCs in acute myocardial infarction is reviewed, focusing on large animal pre-clinical studies and early human trials.
[Cytotherapy]
Raposo, L., Lourenço, A. P., Nascimento, D. S., Cerqueira, R., Cardim, N., & Leite-Moreira, A. (2021). Human umbilical cord tissue-derived mesenchymal stromal cells as adjuvant therapy for myocardial infarction: a review of current evidence focusing on pre-clinical large animal models and early human trials. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.05.002 Cite
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Human Umbilical Cord Mesenchymal Stem Cells in Type 2 Diabetes Mellitus: The Emerging Therapeutic Approach

The authors focus on the latest research and applications of human-derived umbilical cord MSC in the treatment and management of T2DM, exploring and systematizing the key effects of both umbilical cord MSC and its factor-rich secretome accordingly with the major complications associated to T2DM.
[Cell and Tissue Research]
Gomes, A., Coelho, P., Soares, R., & Costa, R. (2021). Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03461-4 Cite
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3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment

PMNT was confirmed to promote human umbilical cord-derived MSC proliferation in a serum-free medium by driving cell cycles and up-regulating gene expression in the pathways of biosynthesis and the metabolism.
[ACS Applied Materials & Interfaces]
Zhao, H., Xu, J., Zhang, E., Qi, R., Huang, Y., Lv, F., Liu, L., Gu, Q., & Wang, S. (2021). 3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c04967 Cite
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Matrigel/Umbilical Cord-Derived Mesenchymal Stem Cells Promote Granulosa Cell Proliferation and Ovarian Vascularization in a Mouse Model of Premature Ovarian Failure

Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
[Stem Cells and Development]
Zhou, yao, Zhou, J., Xu, X., Du, F., Nie, M., Hu, L., Ma, Y., Liu, M., Yu, S., Zhang, J., & Chen, Y. (2021). Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0005 Cite
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Conditioned Medium from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing through Enhanced Angiogenesis

Researchers compared the effectiveness of conditioned medium of MSCs derived from induced pluripotent stem cells with that derived from umbilical cord MSCs in a mouse cutaneous wound healing model.
[Stem Cell Research & Therapy]
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Adult Stem Cells in Endometrial Regeneration: Molecular Insights and Clinical Applications

The authors review the biological mechanisms of endometrial regeneration, and research progress and challenges for adult stem cell therapy for damaged endometrium.
[Molecular Reproduction & Development]
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Allogeneic Human Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells for Chronic Obstructive Pulmonary Disease (COPD): Study Protocol for a Matched Case–Control, Phase I/II Trial

Researchers investigated the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs as a supplementary intervention in combination with standard COPD medication treatments in patients with moderate-to-severe COPD.
[BMJ Open]
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Consecutive Daily Administration of Intratracheal Surfactant and Human Umbilical Cord-Derived Mesenchymal Stem Cells Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats

The authors evaluated the effects of two consecutive days of intratracheal administration of surfactant and human umbilical cord-mesenchymal stem cells on hyperoxia-induced lung injury.
[Stem Cell Research & Therapy]
Chou, H.-C., Chang, C.-H., Chen, C.-H., Lin, W., & Chen, C.-M. (2021). Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung injury in neonatal rats. Stem Cell Research & Therapy, 12(1), 258. https://doi.org/10.1186/s13287-021-02335-4 Cite
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Exosome-Shuttled miR-7162-3p from Human Umbilical Cord Derived Mesenchymal Stem Cells Repair Endometrial Stromal Cell Injury by Restricting APOL6

A damaged-embryonic stem cell (ESC) model and the umbilical cord (UC) MSC co-culture system were established, while GW4869, a noncompetitive neutral sphingomyelinase inhibitor, was used to investigate the effects of UCMSC-exosomes on mifepristone-induced ESC injury.
[Archives of Biochemistry and Biophysics]
Shi, Q., Wang, D., Ding, X., Yang, X., & Zhang, Y. (2021). Exosome-shuttled miR-7162-3p from human umbilical cord derived mesenchymal stem cells repair endometrial stromal cell injury by restricting APOL6. Archives of Biochemistry and Biophysics, 108887. https://doi.org/10.1016/j.abb.2021.108887 Cite
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Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
[International Journal of Molecular Sciences]
Mato-Basalo, R., Morente-López, M., Arntz, O. J., van de Loo, F. A. J., Fafián-Labora, J., & Arufe, M. C. (2021). Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells. International Journal of Molecular Sciences, 22(7), 3367. https://doi.org/10.3390/ijms22073367 Cite
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