Hypoxic Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells Is an Effective Strategy for Treating Acute Lung Injury

When human umbilical cord MSCs were transplanted directly, only a minority of cells migrated toward damaged tissues. Moreover, their maintenance time was short, leading to unsatisfactory therapeutic results.
[Stem Cells and Development]
Wang, Y., Li, H., Li, X., Su, X., Xiao, H., & Yang, J. (2020). Hypoxic Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells Is an Effective Strategy for Treating Acute Lung Injury. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0174 Cite
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Single-Cell Transcriptome Analysis of Uncultured Human Umbilical Cord Mesenchymal Stem Cells

Scientists investigated freshly isolated, uncultured umbilical cord (UC)-MSCs by single-cell RNA sequencing and found two populations of UC-MSCs.
[Stem Cell Research & Therapy]
Zhang, S., Wang, J. Y., Li, B., Yin, F., & Liu, H. (2021). Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells. Stem Cell Research & Therapy, 12(1), 25. https://doi.org/10.1186/s13287-020-02055-1 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-27b Attenuates Subretinal Fibrosis via Suppressing Epithelial–Mesenchymal Transition by Targeting HOXC6

Human umbilical cord-derived mesenchymal stem cells were successfully cultured and identified, and exosomes were isolated from the supernatant by ultracentrifugation.
[Stem Cell Research & Therapy]
Li, D., Zhang, J., Liu, Z., Gong, Y., & Zheng, Z. (2021). Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6. Stem Cell Research & Therapy, 12(1), 24. https://doi.org/10.1186/s13287-020-02064-0 Cite
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Feasibility of Reduced-Dose Posttransplant Cyclophosphamide and Cotransplantation of Peripheral Blood Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells for SAA

Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
[Scientific Reports]
Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Lupus through Increasing CD4+ T Cell Senescence via MiR-199a-5p/Sirt1/p53 Axis

MRL/lpr mice were injected with miR-199a-5p agomir to evaluate the effects of miR-199a-5p on splenic CD4+ T cell senescence and disease in vivo.
[Theranostics]
Cheng, T., Ding, S., Liu, S., Li, Y., & Sun, L. (2021). Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics, 11(2), 893–905. https://doi.org/10.7150/thno.48080 Cite
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Optimization of UC-MSCs Cold-Chain Storage by Minimizing Temperature Fluctuations Using an Automatic Cryopreservation System

To minimize the effect of fluctuation in ambient temperature on stored cells, scientists designed an automatic cryopreservation system that handles cells under controlled temperatures.
[Cryobiology]
Xu, Y., Li-Ying Chan, L., Chen, S., Ying, B., Zhang, T., Liu, W., Guo, H., Wang, J., Xu, Z., Zhang, X., & He, X. (2020). Optimization of UC-MSCs cold-chain storage by minimizing temperature fluctuations using an automatic cryopreservation system. Cryobiology. https://doi.org/10.1016/j.cryobiol.2020.11.010 Cite
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Mechanism of Human Umbilical Cord Mesenchymal Stem Cells Derived-Extracellular Vesicle in Cerebral Ischemia-Reperfusion Injury

After extraction and identification of human umbilical cord MSCs (HMCs)-derived extracellular vesicles, ischemia reperfusion rat models were established and treated with HMC-EVs to measure pathological damage, apoptosis and inflammation in brain tissues.
[Neurochemical Research]
Wang, W., Ji, Z., Yuan, C., & Yang, Y. (2020). Mechanism of Human Umbilical Cord Mesenchymal Stem Cells Derived-Extracellular Vesicle in Cerebral Ischemia-Reperfusion Injury. Neurochemical Research. https://doi.org/10.1007/s11064-020-03179-9 Cite
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Logistics of an Advanced Therapy Medicinal Product during COVID-19 Pandemic in Italy: Successful Delivery of Mesenchymal Stromal Cells in Dry Ice

Researchers assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of umbilical cord-MSCs to clinics.
[Journal of Translational Medicine]
Astori, G., Bernardi, M., Bozza, A., Catanzaro, D., Chieregato, K., Merlo, A., Santimaria, M., Barbazza, R., Amodeo, G., Ciccocioppo, R., Elice, F., & Ruggeri, M. (2020). Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice. Journal of Translational Medicine, 18(1), 451. https://doi.org/10.1186/s12967-020-02625-0 Cite
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Regeneration of a Full-Thickness Defect in Rotator Cuff Tendon with Umbilical Cord-Derived Mesenchymal Stem Cells in a Rat Model

Scientists injected either umbilical cord MSCs or saline to the full-thickness rotator cuff defect and investigated macroscopic, histological and biomechanical results and cell trafficking.
[PLoS One]
Yea, J.-H., Kim, I., Sym, G., Park, J.-K., Lee, A.-Y., Cho, B. C., Bae, T. S., Kim, B. J., & Jo, C. H. (2020). Regeneration of a full-thickness defect in rotator cuff tendon with umbilical cord-derived mesenchymal stem cells in a rat model. PLOS ONE, 15(11), e0235239. https://doi.org/10.1371/journal.pone.0235239 Cite
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miRNA-126-3p Carried by Human Umbilical Cord Mesenchymal Stem Cell Enhances Endothelial Function through Exosome-Mediated Mechanisms In Vitro and Attenuates Vein Graft Neointimal Formation In Vivo

Human umbilical cord MSCs (hucMSCs) and human umbilical vein endothelial cells (HUVECs) were isolated from human umbilical cords and characterized by a series of experiments. Lentivirus vector encoding miRNA-126-3p was transfected into hucMSCs and verified by PCR.
[Stem Cell Research & Therapy]
Qu, Q., Wang, L., Bing, W., Bi, Y., Zhang, C., Jing, X., & Liu, L. (2020). miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo. Stem Cell Research & Therapy, 11(1), 464. https://doi.org/10.1186/s13287-020-01978-z Cite
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Clinical Analysis of Human Umbilical Cord Mesenchymal Stem Cell Allotransplantation in Patients with Premature Ovarian Insufficiency

61 patients diagnosed with premature ovarian insufficiency participated in this study. Umbilical cord-MSCs were isolated and cultured according to GMP standards, and then transplanted to the patients’ ovary by orthotopic injection under the guidance of vaginal ultrasound.
[Cell Proliferation]
Yan, L., Wu, Y., Li, L., Wu, J., Zhao, F., Gao, Z., Liu, W., Li, T., Fan, Y., Hao, J., Liu, J., & Wang, H. (n.d.). Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Proliferation, n/a(n/a), e12938. https://doi.org/10.1111/cpr.12938 Cite
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