Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
[International Journal of Molecular Sciences]
Mato-Basalo, R., Morente-López, M., Arntz, O. J., van de Loo, F. A. J., Fafián-Labora, J., & Arufe, M. C. (2021). Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells. International Journal of Molecular Sciences, 22(7), 3367. https://doi.org/10.3390/ijms22073367 Cite
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Eradication of Specific Donor-Dependent Variations of Mesenchymal Stem Cells in Immunomodulation to Enhance Therapeutic Values

Researchers analyzed human umbilical-cord-derived MSCs from 32 donors and revealed donor-dependent variations in two non-correlated properties; cell proliferation, and immune modulatory functions in vitro and in vivo, which might explain inconsistent clinical efficacies of MSCs.
[Cell Death & Disease]
Zhang, C., Zhou, L., Wang, Z., Gao, W., Chen, W., Zhang, H., Jing, B., Zhu, X., Chen, L., Zheng, C., Shi, K., Wu, L., Cheng, L., Zhang, K., & Sun, Y. E. (2021). Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell Death & Disease, 12(4), 1–11. https://doi.org/10.1038/s41419-021-03644-5 Cite
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Reversion of Early- and Late-Stage β-Cell Dedifferentiation by Human Umbilical Cord-Derived Mesenchymal Stem Cells in Type 2 Diabetic Mice

Investigators observed β-cell dedifferentiation in type 2 diabetes mellitus and investigated the reversal effect of umbilical cord-derived MSCs on early- and late-stage β-cell dedifferentiation.
[Cytotherapy]
Li, B., Cheng, Y., Yin, Y., Xue, J., Yu, S., Gao, J., Liu, J., Zang, L., & Mu, Y. (2021). Reversion of early- and late-stage β-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.005 Cite
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Stem Cell Treatment Improves Post Stroke Neurological Outcomes: A Comparative Study in Male and Female Rats

Researchers hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females, despite any apparent sex differences in post-stroke brain injury.
[Stroke and Vascular Neurology]
Nalamolu, K. R., Chelluboina, B., Fornal, C. A., Challa, S. R., Pinson, D. M., Wang, D. Z., Klopfenstein, J. D., & Veeravalli, K. K. (2021). Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke and Vascular Neurology, svn. https://doi.org/10.1136/svn-2020-000834 Cite
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Biological Characteristics and Metabolic Profile of Canine Mesenchymal Stem Cells Isolated from Adipose Tissue and Umbilical Cord Matrix

Researchers compared the characteristics of canine adipose tissue and umbilical cord matrix MSCs. For the first time in the dog, the cellular bioenergetics were investigated by evaluating the two main metabolic pathways of ATP production.
[PLoS One]
Marcoccia, R., Nesci, S., Merlo, B., Ballotta, G., Algieri, C., Pagliarani, A., & Iacono, E. (2021). Biological characteristics and metabolic profile of canine mesenchymal stem cells isolated from adipose tissue and umbilical cord matrix. PLOS ONE, 16(3), e0247567. https://doi.org/10.1371/journal.pone.0247567 Cite
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MSCs Derived from Amniotic Fluid and Umbilical Cord Require Different Administration Schemes and Exert Different Curative Effects on Different Tissues in Rats with CLP-Induced Sepsis

Investigators generated rats with medium-grade sepsis with a 30–40% survival rate to study the curative effects of amniotic fluid-MSCs and umbilical cord-MSCs. MSCs reversed cecal ligation and puncture-induced changes in proinflammatory cytokine levels and coagulation activation.
[Stem Cell Research & Therapy]
Chen, R., Xie, Y., Zhong, X., Chen, F., Gong, Y., Wang, N., & Wang, D. (2021). MSCs derived from amniotic fluid and umbilical cord require different administration schemes and exert different curative effects on different tissues in rats with CLP-induced sepsis. Stem Cell Research & Therapy, 12(1), 164. https://doi.org/10.1186/s13287-021-02218-8 Cite
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Influence of Piper betle L. Extract on Umbilical Cord Cells In Vitro and Potential Treating Cutaneous Wound

Scientists tested the effects of Piper betle L. from Vietnam on fibroblasts and umbilical cord (UC)-derived mesenchymal stem cells from human UC on the scratch assay.
[Heliyon]
Thị, C. H. C., Nguyễn, H. Đ., & Hoàng, D. M. L. (2021). Influence of Piper betle L. extract on umbilical cord cells in vitro and potential treating cutaneous wound. Heliyon, 7(3). https://doi.org/10.1016/j.heliyon.2021.e06248 Cite
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Mesenchymal Stem Cells Alleviate Experimental Immune-Mediated Liver Injury via Chitinase 3-Like Protein 1-Mediated T Cell Suppression

Downregulating chitinase-3-like protein 1 mitigated the ability of human umbilical cord-mesenchymal stem cells to inhibit T cell activation, proliferation and inflammatory cytokine secretion in vitro.
[Cell Death & Disease]
Liu, Q., Chen, X., Liu, C., Pan, L., Kang, X., Li, Y., Du, C., Dong, S., Xiang, A. P., Xu, Y., & Zhang, Q. (2021). Mesenchymal stem cells alleviate experimental immune-mediated liver injury via chitinase 3-like protein 1-mediated T cell suppression. Cell Death & Disease, 12(3), 1–15. https://doi.org/10.1038/s41419-021-03524-y Cite
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Mesenchymal Stem Cell Exosome-Derived miR-223 Alleviates Acute Graft-versus-Host Disease via Reducing the Migration of Donor T Cells

Investigators performed expression profiling of exosome-miRNAs from human umbilical cord mesenchymal stem cells (MSCs) and murine compact bone MSCs to investigate their immunoregulation effects in acute graft-versus-host disease.
[Stem Cell Research & Therapy]
Liu, W., Zhou, N., Liu, Y., Zhang, W., Li, X., Wang, Y., Zheng, R., & Zhang, Y. (2021). Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells. Stem Cell Research & Therapy, 12(1), 153. https://doi.org/10.1186/s13287-021-02159-2 Cite
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Macrophage Migration Inhibitory Factor Facilitates the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Acute Myocardial Infarction through Upregulating miR-133a-3p

Exosomes isolated from umbilical cord mesenchymal stem cells MSCs (ucMSC-Exo), MIF engineered ucMSCs (MIF-Exo) and MIF downregulated ucMSCs were used to investigate cellular protective function in human umbilical vein endothelial cells and H9C2 cardiomyocytes under hypoxia and serum deprivation and infarcted hearts in rats.
[Journal of Nanobiotechnology]
Zhu, W., Sun, L., Zhao, P., Liu, Y., Zhang, J., Zhang, Y., Hong, Y., Zhu, Y., Lu, Y., Zhao, W., Chen, X., & Zhang, F. (2021). Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p. Journal of Nanobiotechnology, 19(1), 61. https://doi.org/10.1186/s12951-021-00808-5 Cite
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Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging

Researchers isolated exosomes derived from umbilical cord MSCs grown in a 3D culture system and explored their ability to modulate the photo-aging of HaCaT keratinocytes.
[Rejuvenation Research]
Liu, S.-J., Meng, M.-Y., Han, S., Gao, H., Zhao, Y.-Y., Yang, Y., Lin, Z.-Y., Yang, L.-R., Zhu, K., Han, R., Huang, W.-W., Wang, R.-Q., Yang, L.-L., Wang, W.-J., Li, L., Wang, X.-D., Hou, Z.-L., Liao, L. W., & Yang, L. (2021). Umbilical cord mesenchymal stem cell-derived exosomes ameliorate HaCaT cell photo-aging. Rejuvenation Research. https://doi.org/10.1089/rej.2020.2313 Cite
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