Mesenchymal Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model

Investigators report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function.
[Brain Research Bulletin]
Pourmohammadi-Bejarpasi, Z., Roushandeh, A. M., Saberi, A., Rostami, M. K., Toosi, S. M. R., Jahanian-Najafabadi, A., Tomita, K., Kuwahara, Y., Sato, T., & Roudkenar, M. H. (2020). Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model. Brain Research Bulletin, 165, 70–80. https://doi.org/10.1016/j.brainresbull.2020.09.018 Cite
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Regeneration of a Full-Thickness Defect of Rotator Cuff Tendon with Freshly Thawed Umbilical Cord-Derived Mesenchymal Stem Cells in a Rat Model

Researchers evaluated morphology, viability, and proliferation of cultured umbilical cord-derived MSCs and freshly thawed umbilical cord-derived MSCs at passage 10 in vitro.
[Stem Cell Research & Therapy]
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A Non-Biodegradable Scaffold-Free Cell Sheet of Genome-Engineered Mesenchymal Stem Cells Inhibits Development of Acute Kidney Injury

By exploiting genome editing technology, human umbilical cord-derived MSCs secreting an angiogenic factors or an anti-inflammatory factor were generated for therapeutic application in acute kidney injury.
[Kidney International]
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy in Patients with COVID-19: A Phase I Clinical Trial

Investigators performed a controlled, non-randomized, Phase I clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.
[Signal Transduction and Targeted Therapy]
Meng, F., Xu, R., Wang, S., Xu, Z., Zhang, C., Li, Y., Yang, T., Shi, L., Fu, J., Jiang, T., Huang, L., Zhao, P., Yuan, X., Fan, X., Zhang, J.-Y., Song, J., Zhang, D., Jiao, Y., Liu, L., … Wang, F.-S. (2020). Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial. Signal Transduction and Targeted Therapy, 5(1), 1–7. https://doi.org/10.1038/s41392-020-00286-5 Cite
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Magnetic Resonance Imaging of Umbilical Cord Stem Cells Labeled with Superparamagnetic Iron Oxide Nanoparticles: Effects of Labelling and Transplantation Parameters

The authors examined umbilical cord-derived mesenchymal stem cells labeled with superparamagnetic and ultrasmall superparamagnetic iron oxide in terms of cell functioning and imaging efficiency in vitro and in vivo.
[Scientific Reports]
Ohki, A., Saito, S., & Fukuchi, K. (2020). Magnetic resonance imaging of umbilical cord stem cells labeled with superparamagnetic iron oxide nanoparticles: effects of labelling and transplantation parameters. Scientific Reports, 10(1), 13684. https://doi.org/10.1038/s41598-020-70291-9 Cite
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Magnetic Resonance Imaging of Umbilical Cord Stem Cells Labeled with Superparamagnetic Iron Oxide Nanoparticles: Effects of Labeling and Transplantation Parameters

Scientists examined the umbilical cord-MSCs labeled with superparamagnetic and ultrasmall superparamagnetic iron oxide in terms of cell functioning and imaging efficiency in vitro and in vivo.
[Scientific Reports]
Ohki, A., Saito, S., & Fukuchi, K. (2020). Magnetic resonance imaging of umbilical cord stem cells labeled with superparamagnetic iron oxide nanoparticles: effects of labelling and transplantation parameters. Scientific Reports, 10(1), 13684. https://doi.org/10.1038/s41598-020-70291-9 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
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Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review

The authors systematically review literature pertaining to hematopoietic stem cell (HSC) based tissue engineering strategies in animal models of chondral repair such that trends may be identified and the utility of HSCs in chondral repair can be elucidated
[Tissue Engineering]
Kabir, W., Di Bella, C., Gould, D., Jo, I., & Choong, P. (2020). Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.TEB.2020.0155 Cite
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Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study

67 patients were treated with Wharton’s jelly mesenchymal stem cells. The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 amyotrophic lateral sclerosis clinical studies
[Stem Cell Reviews and Reports]
Barczewska, M., Maksymowicz, S., Zdolińska-Malinowska, I., Siwek, T., & Grudniak, M. (2020). Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10016-7 Cite
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Comparison of Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Isolated from Cryopreserved Material and Extracted by Explantation and Digestion Methods Utilizing a Split Manufacturing Model

Umbilical cord (UC)-derived MSCs were isolated from 10 UC tissue samples by both explantation and enzymatic digestion methods to allow for comparison of cells from the same donor.
[Cytotherapy]
Skiles, M. L., Marzan, A. J., Brown, K. S., & Shamonki, J. M. (2020). Comparison of umbilical cord tissue-derived mesenchymal stromal cells isolated from cryopreserved material and extracted by explantation and digestion methods utilizing a split manufacturing model. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.06.002 Cite
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Neonatal Genetics of Gene Expression Reveal Potential Origins of Autoimmune and Allergic Disease Risk

Investigators mapped expression quantitative trait loci in resting myeloid cells and CD4+ T cells from cord blood samples, as well as in response to lipopolysaccharide or phytohemagglutinin stimulation, respectively.
[Nature Communications]
Huang, Q. Q., Tang, H. H. F., Teo, S. M., Mok, D., Ritchie, S. C., Nath, A. P., Brozynska, M., Salim, A., Bakshi, A., Holt, B. J., Khor, C. C., Sly, P. D., Holt, P. G., Holt, K. E., & Inouye, M. (2020). Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk. Nature Communications, 11(1), 3761. https://doi.org/10.1038/s41467-020-17477-x Cite
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