UC-MSCs

[International Journal of Molecular Sciences] The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.

[Cell Death & Disease] Researchers analyzed human umbilical-cord-derived MSCs from 32 donors and revealed donor-dependent variations in two non-correlated properties; cell proliferation, and immune modulatory functions in vitro and in vivo, which might explain inconsistent clinical efficacies of MSCs.

[Cytotherapy] Investigators observed β-cell dedifferentiation in type 2 diabetes mellitus and investigated the reversal effect of umbilical cord-derived MSCs on early- and late-stage β-cell dedifferentiation.

[Stroke and Vascular Neurology] Researchers hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females, despite any apparent sex differences in post-stroke brain injury.

[PLoS One] Researchers compared the characteristics of canine adipose tissue and umbilical cord matrix MSCs. For the first time in the dog, the cellular bioenergetics were investigated by evaluating the two main metabolic pathways of ATP production.

[Stem Cell Research & Therapy] Investigators generated rats with medium-grade sepsis with a 30–40% survival rate to study the curative effects of amniotic fluid-MSCs and umbilical cord-MSCs. MSCs reversed cecal ligation and puncture-induced changes in proinflammatory cytokine levels and coagulation activation.